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ritrosulfan

Known as: ritosulfan, Lycurim, lykurim 
A sulfonate-based alkylation agent with potential antineoplastic activity. Ritrosulfan appears to alkylate DNA, thereby producing DNA crosslinks… 
National Institutes of Health

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Broader (3)

Antineoplastic AgentsAntineoplastic Agents, AlkylatingErythritol

Narrower (1)

R-74
analogs & derivatives

Papers overview

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1984
1984
[Lycurim, lymphomas and cytostatic trials].
1983
1983
Effects of some sugar alcohol derivatives on mutation and induction of sister chromatid exchanges.
The mutagenicity of various alkylating sugar alcohol derivatives in the Salmonella-microsome assay was studied, and the effects… 
1983
1983
Chemotherapeutic sensitivity of liver metastases from intrasplenically-growing Lewis lung tumor
A recently developed metastatic tumor model was used to study the therapeutic response of liver metastases derived from… 
1982
1982
Action of lycurim and pyrazofurin on hepatoma 3924A cells in culture.
The purpose of this study was to test for a possible synergism in the antitumor action of the antimetabolite pyrazofurin (PF) and… 
1981
1981
Lycurim (R-74) in the therapy of chronic lymphocytic leukaemia.
Lycurim was used in the therapy of 41 CLL patients, in 34 a positive clinical effect was found. The effect was marked in cases of… 
1981
1981
Evaluation of the therapeutic effect of lycurim in lymphoma.
1980
1980
Chemical reactivity and intracavitary application of alkylating sugar alcohol derivatives.
Lycurium [1,4-di-(methylsulfonyloxy-ethylamino)-1,4-didesoxy-erythrioldimethylsulfonate; R-74; NSC-122402] undergoes rapid… 
1980
1980
[Lycurim in the treatment of patients with chronic lymphocytic leukemia (author's transl)].
1978
1978
Studies of the growth of an ascitic tumour. II. A system to study the tumour-age dependent effect of antitumour agents.
1976
1976
Cross-resistance of transformed mouse cells to some drugs.
The Colcemid-resistant L--53 cell strain was examined for cross-resistance to metaphase inhibotors (Vincristine, Vinblastine… 
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