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riddelliine

Known as: 13,19-didehydro-12,18-dihydroxysenecionan-11,16-dione 
National Institutes of Health

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Broader (1)

Pyrrolizidine Alkaloids

Papers overview

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Highly Cited
2006
Highly Cited
2006
Formation of DHP-derived DNA adducts from metabolic activation of the prototype heliotridine-type pyrrolizidine alkaloid, lasiocarpine.
2004
2004
Mutations induced by the carcinogenic pyrrolizidine alkaloid riddelliine in the liver cII gene of transgenic big blue rats.
Riddelliine is a naturally occurring pyrrolizidine alkaloid that forms a number of different mononucleotide and dinucleotide… 
2004
2004
Application of a statistical dynamic model investigating the short-term cellular kinetics induced by riddelliine, a hepatic endothelial carcinogen.
In recent studies, riddelliine, a pyrrolizidine alkaloid, was found to increase rates of replication and apoptosis and induce… 
2004
2004
Evaporative light scattering detection of pyrrolizidine alkaloids.
A reverse-phase high-performance liquid chromatography method utilizing evaporative light scattering detection (ELSD) has been… 
Highly Cited
2003
Highly Cited
2003
Human liver microsomal metabolism and DNA adduct formation of the tumorigenic pyrrolizidine alkaloid, riddelliine.
Riddelliine, a widespread naturally occurring genotoxic pyrrolizidine alkaloid, induced liver tumors in rats and mice in an NTP 2… 
2003
2003
Correlation of DNA adduct formation and riddelliine-induced liver tumorigenesis in F344 rats and B6C3F(1) mice.
2002
2002
Detection of Riddelliine-Derived DNA Adducts in Blood of Rats Fed Riddelliine
We have previously shown that riddelliine, a naturally occurring genotoxic pyrrolizidine alkaloid, induces liver tumors in rats… 
2002
2002
The hepatic endothelial carcinogen riddelliine induces endothelial apoptosis, mitosis, S phase, and p53 and hepatocytic vascular endothelial growth factor expression after short-term exposure.
Riddelliineis a naturally occurring pyrrolizidine alkaloid found in certain poisonous rangeland plants of the western United… 
2000
2000
GC/MS/MS detection of pyrrolic metabolites in animals poisoned with the pyrrolizidine alkaloid riddelliine.
Pyrrolic metabolites from pyrrolizidine alkaloids (PAs) were detected in liver and dried blood samples using a gas chromatography… 
1996
1996
Preparative separation of pyrrolizidine alkaloids by high-speed counter-current chromatography.
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