ridaforolimus

Known as: Deforolimus, Rapamycin, 42-(dimethylphosphinate) 
A small molecule and non-prodrug analogue of the lipophilic macrolide antibiotic rapamycin with potential antitumor activity. Ridaforolimus binds to… (More)
National Institutes of Health

Papers overview

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2014
2014
OBJECTIVE The phosphatidylinositol-3 kinase/serine-threonine kinase PI3K/AKT pathway is postulated to be central to cancer cell… (More)
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2013
2013
Background:This open-label, multicentre, phase 2 trial evaluated the efficacy and tolerability of the mammalian target of… (More)
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Highly Cited
2012
Highly Cited
2012
PURPOSE Ridaforolimus is an inhibitor of mammalian target of rapamycin, an integral component of the phosphatidyl 3-kinase/AKT… (More)
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2012
2012
Although androgen ablation therapy is the foundation of current prostate cancer treatment, most patients ultimately… (More)
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Review
2011
Review
2011
Ridaforolimus (deforolimus; AP23573; MK-8669) is a novel sirolimus derivative manufactured by ARIAD Pharmaceuticals and acquired… (More)
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Review
2010
Review
2010
Mammalian target of rapamycin (mTOR) is a protein kinase of the PI3K/Akt signaling pathway. Activation of mTOR in response to… (More)
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2010
2010
PURPOSE Synergistic/additive cytotoxicity in tumor models and widespread applicability of fluoropyrimidines in solid tumors… (More)
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Review
2009
Review
2009
Since the discovery of rapamycin, considerable progress has been made in unraveling the details of the mammalian target of… (More)
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Review
2009
Review
2009
The mammalian target of rapamycin (mTOR) is an intracellular serine/threonine protein kinase positioned at a central point in a… (More)
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Review
2009
Review
2009
Chemotherapy, biological agents or combinations of both have had little impact on survival of patients with metastatic melanoma… (More)
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