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retroviral strand transfer activity

Known as: strand transfer reaction 
Catalysis of the covalent insertion of processed 3'-viral DNA ends into host chromosomal DNA by a trans-esterification reaction. [PMID:22580823]
National Institutes of Health

Papers overview

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2019
2019
Dual HIV-1 reverse transcriptase and integrase inhibitors from Limonium morisianum Arrigoni, an endemic species of Sardinia (Italy)
Abstract During our search for potential templates of HIV-1 reverse transcriptase (RT) and integrase (IN) dual inhibitors, the… 
2011
2011
Fragment‐Based Design of Ligands Targeting a Novel Site on the Integrase Enzyme of Human Immunodeficiency Virus 1
Fragment-based screening has been used to identify a novel ligand binding site on HIV-1 integrase. Crystal structures of… 
Review
2010
Review
2010
GSK-1349572, a novel integrase inhibitor for the treatment of HIV infection.
GSK-1349572 (S/GSK-1349572), under development by ViiV Healthcare and Shionogi & Co Ltd, is the lead from a series of HIV… 
2007
2007
HIV-1 integrase preassembled on donor DNA is refractory to activity stimulation by LEDGF/p75.
LEDGF/p75 is known to enhance the integrase strand transfer activity in vitro, but the underlying mechanism is unclear. Using an… 
Highly Cited
2005
Highly Cited
2005
Dynamic receptor-based pharmacophore model development and its application in designing novel HIV-1 integrase inhibitors.
We present here a dynamic receptor-based pharmacophore model representing the complementary features of the active site region of… 
1999
1999
Inhibitors of DNA strand transfer reactions catalyzed by HIV-1 reverse transcriptase.
The discovery and characterization of new inhibitors of HIV-1 reverse transcriptase (RT) is an important step toward… 
1998
1998
Mutations in domain III alpha of the Mu transposase: evidence suggesting an active site component which interacts with the Mu-host junction.
A series of point mutations was constructed in domain IIIalpha of the Mu A protein. The mutant transposases were purified and… 
1992
1992
Flanking host sequences can exert an inhibitory effect on the cleavage step of the in vitro mu DNA strand transfer reaction.
Highly Cited
1990
Highly Cited
1990
Immunoelectron microscopic analysis of the A, B, and HU protein content of bacteriophage Mu transpososomes.
Highly Cited
1984
Highly Cited
1984
Mechanism of transposition of bacteriophage mu: polarity of the strand transfer reaction at the initiation of transposition
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