retroviral strand transfer activity

Known as: strand transfer reaction 
Catalysis of the covalent insertion of processed 3'-viral DNA ends into host chromosomal DNA by a trans-esterification reaction. [PMID:22580823]
National Institutes of Health

Papers overview

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2003
2003
Nucleic acid conformational changes essential for HIV-1 nucleocapsid protein-mediated inhibition of self-priming in minus-strand transfer.
Reverse transcription of the HIV-1 genome is a complex multi-step process. HIV-1 nucleocapsid protein (NC) is a nucleic acid… (More)
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Highly Cited
2002
Highly Cited
2002
Diketo acid inhibitor mechanism and HIV-1 integrase: implications for metal binding in the active site of phosphotransferase enzymes.
The process of integrating the reverse-transcribed HIV-1 DNA into the host chromosomal DNA is catalyzed by the virally encoded… (More)
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2000
2000
Trans catalysis in Tn5 transposition.
Synaptic complexes in prokaryotic transposons occur when transposase monomers bind to each of two specific end-binding sequences… (More)
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1995
1995
Identification of the nicking tyrosine of geminivirus Rep protein.
The replication initiator (Rep) proteins of geminiviruses perform a DNA cleavage and strand transfer reaction at the viral origin… (More)
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1995
1995
Strand transfer mediated by human immunodeficiency virus reverse transcriptase in vitro is promoted by pausing and results in misincorporation.
Human immunodeficiency virus (HIV-1) is able to recombine by transfer of the growing DNA strand from internal regions of one… (More)
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Highly Cited
1995
Highly Cited
1995
Catalytic domain of human immunodeficiency virus type 1 integrase: identification of a soluble mutant by systematic replacement of hydrophobic residues.
The integrase protein of human immunodeficiency virus type 1 is necessary for the stable integration of the viral genome into… (More)
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1994
1994
Transactivation of the minus-strand DNA transfer by nucleocapsid protein during reverse transcription of the retroviral genome.
Two DNA strand transfers are required during reverse transcription of the RNA genome of retroviruses to complete provirus… (More)
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Highly Cited
1994
Highly Cited
1994
Hepadnavirus reverse transcription initiates within the stem-loop of the RNA packaging signal and employs a novel strand transfer.
Replication of the hepadnavirus genome occurs by reverse transcription of an RNA pregenome and is mediated by the viral… (More)
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1994
1994
A new component of bacteriophage Mu replicative transposition machinery: the Escherichia coli ClpX protein.
We have shown previously that some particular mutations in bacteriophage Mu repressor, the frameshift vir mutations, made the… (More)
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Highly Cited
1991
Highly Cited
1991
HIV-1 DNA integration: Mechanism of viral DNA cleavage and DNA strand transfer
Retroviral DNA integration involves a coordinated set of DNA cutting and joining reactions. Linear viral DNA is cleaved at each 3… (More)
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