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retroviral strand transfer activity
Known as:
strand transfer reaction
Catalysis of the covalent insertion of processed 3'-viral DNA ends into host chromosomal DNA by a trans-esterification reaction. [PMID:22580823]
National Institutes of Health
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Highly Cited
2004
Highly Cited
2004
Interaction between Human Immunodeficiency Virus Type 1 Reverse Transcriptase and Integrase Proteins
Eric A. Hehl
,
P. Joshi
,
G. Kalpana
,
V. Prasad
Journal of Virology
2004
Corpus ID: 19587506
ABSTRACT Reverse transcriptase (RT) and integrase (IN) are two key catalytic enzymes encoded by all retroviruses. It has been…
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Highly Cited
2004
Highly Cited
2004
Mechanism of HIV-1 integrase inhibition by styrylquinoline derivatives in vitro.
E. Deprez
,
S. Barbe
,
+6 authors
J. Mouscadet
Molecular pharmacology
2004
Corpus ID: 29052691
Styrylquinoline derivatives (SQ) efficiently inhibit the 3'-processing activity of integrase (IN) with IC50 values of between 0.5…
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Highly Cited
2002
Highly Cited
2002
Diketo acid inhibitor mechanism and HIV-1 integrase: Implications for metal binding in the active site of phosphotransferase enzymes
J. Grobler
,
K. Stillmock
,
+11 authors
D. Hazuda
Proceedings of the National Academy of Sciences…
2002
Corpus ID: 2703518
The process of integrating the reverse-transcribed HIV-1 DNA into the host chromosomal DNA is catalyzed by the virally encoded…
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Highly Cited
1996
Highly Cited
1996
(-)-Arctigenin as a lead structure for inhibitors of human immunodeficiency virus type-1 integrase.
E. Eich
,
H. Pertz
,
+4 authors
Y. Pommier
Journal of medicinal chemistry
1996
Corpus ID: 36960191
The natural dibenzylbutyrolactone type lignanolide (-)-arctigenin (2), an inhibitor of human immunodeficiency virus type-1 (HIV-1…
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Highly Cited
1995
Highly Cited
1995
Influence of Human Immunodeficiency Virus Nucleocapsid Protein on Synthesis and Strand Transfer by the Reverse Transcriptase in Vitro(*)
Lorna Rodrguez-Rodrguez
,
Z. Tsuchihashi
,
G. M. Fuentes
,
R. Bambara
,
P. Fay
The Journal of Biological Chemistry
1995
Corpus ID: 38744803
Human immunodeficiency virus (HIV) nucleocapsid protein (NC) influences HIV reverse transcriptase (RT) catalyzed strand transfer…
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Highly Cited
1994
Highly Cited
1994
Hepadnavirus reverse transcription initiates within the stem-loop of the RNA packaging signal and employs a novel strand transfer
J. Tavis
,
S. Perri
,
D. Ganem
Journal of virology
1994
Corpus ID: 21302368
Replication of the hepadnavirus genome occurs by reverse transcription of an RNA pregenome and is mediated by the viral…
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Highly Cited
1991
Highly Cited
1991
HIV-1 DNA integration: Mechanism of viral DNA cleavage and DNA strand transfer
A. Engelman
,
K. Mizuuchi
,
R. Craigie
Cell
1991
Corpus ID: 1721232
Highly Cited
1991
Highly Cited
1991
Structural aspects of a higher order nucleoprotein complex: induction of an altered DNA structure at the Mu‐host junction of the Mu type 1 transpososome.
B. Lavoie
,
B. Chan
,
R. G. Allison
,
G. Chaconas
The EMBO journal
1991
Corpus ID: 23252095
The Mu in vitro strand transfer reaction proceeds via two stable higher order nucleoprotein complexes, the Type 1 and Type 2…
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Highly Cited
1990
Highly Cited
1990
Escherichia coli RecQ protein is a DNA helicase.
K. Umezu
,
K. Nakayama
,
H. Nakayama
Proceedings of the National Academy of Sciences…
1990
Corpus ID: 35358358
The Escherichia coli recQ gene, a member of the RecF recombination gene family, was set in an overexpression plasmid, and its…
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Highly Cited
1987
Highly Cited
1987
Transpososomes: Stable protein-DNA complexes involved in the in vitro transposition of bacteriophage Mu DNA
M. Surette
,
S. Buch
,
G. Chaconas
Cell
1987
Corpus ID: 2321552
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