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response to simvastatin

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene… Expand
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
AIMS Statins reduce LDL cholesterol (LDL-C) and the risk of vascular events, but it remains uncertain whether there is clinically… Expand
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Highly Cited
2011
Highly Cited
2011
Although statins are widely prescribed medications, there remains considerable variability in therapeutic response. Genetics can… Expand
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Highly Cited
2010
Highly Cited
2010
Statins are commonly used for reducing cardiovascular disease risk but therapeutic benefit and reductions in levels of low… Expand
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2010
2010
OBJECTIVE Although statins are efficacious for lowering low-density lipoprotein cholesterol, there is wide interindividual… Expand
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Highly Cited
2008
Highly Cited
2008
BACKGROUND Use of 3-hydroxyl-3-methylglutaryl-3 coenzyme A reductase (HMGCR) inhibitors, or statins, reduces cardiovascular… Expand
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Highly Cited
2008
Highly Cited
2008
BACKGROUND HMGCR(3-Hydroxy-3-methylglutaryl coenzyme A reductase), the direct target of statin inhibition, undergoes alternative… Expand
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Highly Cited
2006
Highly Cited
2006
Although statins are effective lipid-lowering agents, the phenotypic and demographic predictors of such lowering have been less… Expand
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Highly Cited
2001
Highly Cited
2001
BACKGROUND Patients with low HDL cholesterol (HDL-C) and elevated triglyceride had an increased risk for coronary heart disease… Expand
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1998
1998
In familial hypercholesterolemia (FH), the efficacy of the inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA… Expand
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1990
1990
In a group of 120 patients with heterozygous familial hypercholesterolemia (FH) the influence of the apolipoprotein E (apoE… Expand
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