regulation of actin filament organisation of cytokinesis, actomyosin ring biosynthesis

Polymers are being used in a wide range of Additive Manufacturing (AM) applications and have been shown to have tremendous… (More)

 

The duration of phase 2 of a transient after sudden reduction of the length of a muscle or a load on it decreases rapidly with… (More)

In this paper, we study the evolution of the vortex filament equation (VFE), 

. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 REVIEW OF THE LITERATURE . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 1. The Cytoskeleton . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 2. Actin. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 3. Actin Binding Proteins (Abps) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11 3.1 Actin Filament Nucleators . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12 3.2 Actin Monomer Binding Proteins . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13 4. CONTRACTILE PROTEINS IN MUSCLES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15 4.1 Structure and Function of Sarcomere . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15 4.2 Sarcomeric Proteins . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 16 4.2.1 Thick filament proteins. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 16 4.2.2 Thin filament proteins . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 16 4.2.3 Zdisc proteins . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 18 4.2.4 Giant muscle proteins . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 18 4.3 Actin Dynamics in Muscle . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 20 5. Aberrations Of Contractile Proteins And Myofibril Abnormalities . . . . . . . . . . . . . . . . 20 AIMS OF THE STUDY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 23 MATERIALS AND METHODS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 24 RESULTS AND DISCUSSION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25 6. Actin dynamics in heart muscle cells . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25 6.1 Contractility-dependent actin dynamics in cardiomyocyte sarcomeres (I). . . . 25 6.2 Dynamic actin pool is composed of filaments that do not contribute to the contractility (I) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25 6.3 Proper assembly of actin filaments in cardiomyocytes depends on contractility (I and III) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 26 7. Proteins involved in actin rearrangements in muscle cells . . . . . . . . . . . . . . . . . . . . . . . 27 7.1 Identification of novel actin nucleator in muscle cells leiomodin (II and III) 27 7.2 Localization and dynamics of leiomodin in muscle cells (II and III) . . . . . . . . . . 28 7.3 Role of Lmod in sarcomere assembly and/or maintenance (II and III) . . . . . . . 28 7.4 ADF/cofilins are essential for the correct organization of sarcomeric actin arrays (I) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 29 7.5 Localization of twinfilin isoforms in muscle cells (IV) . . . . . . . . . . . . . . . . . . . . . . 30 CONCLUDING REMARKS AND FUTURE DIRECTIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 31 ACKNOWLEDGEMENTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 34 REFERENCES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 36 Review Of The Literature 

Applications of the work introduced by the authors in a recent article, Filament sets and homogeneous continua, are given to… (More)

While the remodeling process in myocardial failure involves changes in ventricular structure and performance, it is now… (More)

 

It is usually accepted that the phenomenon of thick filament shortening contradicts the sliding filament theory and cross-bridge… (More)