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Multiple data suggest that the renin-angiotensin system contributes to the pathogenesis of atherosclerosis. The atherogenic… Expand BACKGROUND
ACE (kininase II) inhibitors have been shown to exert their beneficial cardiovascular effects via the inhibition of… Expand BACKGROUND
Attenuation of myocardial stunning by several angiotensin-converting enzyme (ACE) inhibitors has been demonstrated… Expand We wished to determine, using a novel specific antagonist of BK2, HOE 140, (a) if the angiotensin-converting enzyme (ACE… Expand To establish that bradykinin is formed in the heart we measured bradykinin in the venous effluent from rat isolated hearts… Expand The angiotensin-converting enzyme inhibitor ramiprilat, the angiotensin II receptor antagonist losartan, angiotensin II… Expand We investigated the role of kinins in the acute depressor effect of captopril and ramiprilat in spontaneously hypertensive rats… Expand We studied whether inhibition of angiotensin converting enzyme stimulates the formation of nitric oxide and prostacyclin in… Expand We investigated the role of local (cardiac) bradykinin in the infarct-limiting effect of the ACE inhibitor, ramiprilat, by using… Expand Components of the renin-angiotensin system (RAS) have been found in heart tissue and it is likely that angiotensin II (ANG II) is… Expand