ral Guanine Nucleotide Exchange Factor
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Significance KRAS (Kirsten rat sarcoma viral oncogene homolog) is frequently mutated in pancreatic, colon, and lung tumors, which… Expand The spectrum of tumors associated with oncogenic Ras in humans often differs from those in mice either treated with carcinogens… Expand β-Arrestins are important in chemoattractant receptor-induced granule release, a process that may involve Ral-dependent… Expand ABSTRACT Activated Ras, but not Raf, causes transformation of RIE-1 rat intestinal epithelial cells, demonstrating the importance… Expand ABSTRACT AFX is a Forkhead transcription factor that induces a G1 cell cycle arrest via upregulation of the cell cycle inhibitor… Expand The interactions of H-Ras, R-Ras, and Rap1A with the Ras-binding domains (RBD) of the c-Raf kinase and of the Ral guanine… Expand Ral proteins (RalA and RalB) comprise a distinct family of Ras‐related GTPases (Feig and Emkey, 1993). Recently, Ral‐GDS, the… Expand To identify proteins that bind to the Ras-related protein R-ras we performed a yeast two-hybrid cDNA library screen. Several… Expand Using a yeast two-hybrid system, we identified a novel protein which interacts with ras p21. This protein shares 69% amino acid… Expand ras‐related GTPases participate in signaling for a variety of cellular processes. The GTPases cycle between a GTP‐bound active… Expand