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ral Guanine Nucleotide Exchange Factor

Known as: ral GDS, RGF, ral Guanine Nucleotide Exchange Factor [Chemical/Ingredient] 
Encoded by human RALGDS Gene, 914-aa 101-kDa RAL Guanine Nucleotide Dissociation Stimulator is a guanine nucleotide exchange factor containing an N… 
National Institutes of Health

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In BloodProcess of secretionRALGDS geneRALGDS wt Allele

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Rgl3 protein, mouse

Papers overview

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Highly Cited
2015
Highly Cited
2015
Oncogenic and RASopathy-associated K-RAS mutations relieve membrane-dependent occlusion of the effector-binding site
Significance KRAS (Kirsten rat sarcoma viral oncogene homolog) is frequently mutated in pancreatic, colon, and lung tumors, which… 
Highly Cited
2005
Highly Cited
2005
RalGDS is required for tumor formation in a model of skin carcinogenesis.
Review
2002
Review
2002
Distinct requirements for Ras oncogenesis in human versus mouse cells.
The spectrum of tumors associated with oncogenic Ras in humans often differs from those in mice either treated with carcinogens… 
Highly Cited
2002
Highly Cited
2002
β-Arrestins regulate a Ral-GDS–Ral effector pathway that mediates cytoskeletal reorganization
β-Arrestins are important in chemoattractant receptor-induced granule release, a process that may involve Ral-dependent… 
Highly Cited
2001
Highly Cited
2001
Oncogenic Ras Blocks Anoikis by Activation of a Novel Effector Pathway Independent of Phosphatidylinositol 3-Kinase
ABSTRACT Activated Ras, but not Raf, causes transformation of RIE-1 rat intestinal epithelial cells, demonstrating the importance… 
Highly Cited
2001
Highly Cited
2001
Signal Pathways Which Promote Invasion and Metastasis: Critical and Distinct Contributions of Extracellular Signal-Regulated Kinase and Ral-Specific Guanine Exchange Factor Pathways
ABSTRACT Approximately 50% of metastatic tumors contain Ras mutations. Ras proteins can activate at least three downstream… 
Highly Cited
1996
Highly Cited
1996
Differential Interaction of the Ras Family GTP-binding Proteins H-Ras, Rap1A, and R-Ras with the Putative Effector Molecules Raf Kinase and Ral-Guanine Nucleotide Exchange Factor
The interactions of H-Ras, R-Ras, and Rap1A with the Ras-binding domains (RBD) of the c-Raf kinase and of the Ral guanine… 
Highly Cited
1996
Highly Cited
1996
Ral‐GTPases mediate a distinct downstream signaling pathway from Ras that facilitates cellular transformation.
Ral proteins (RalA and RalB) comprise a distinct family of Ras‐related GTPases (Feig and Emkey, 1993). Recently, Ral‐GDS, the… 
Highly Cited
1994
Highly Cited
1994
ralGDS family members interact with the effector loop of ras p21
Using a yeast two-hybrid system, we identified a novel protein which interacts with ras p21. This protein shares 69% amino acid… 
Highly Cited
1993
Highly Cited
1993
Characterization of a guanine nucleotide dissociation stimulator for a ras‐related GTPase.
ras‐related GTPases participate in signaling for a variety of cellular processes. The GTPases cycle between a GTP‐bound active… 
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