ral Guanine Nucleotide Exchange Factor

Known as: ral GDS, RGF, ral Guanine Nucleotide Exchange Factor [Chemical/Ingredient] 
Encoded by human RALGDS Gene, 914-aa 101-kDa RAL Guanine Nucleotide Dissociation Stimulator is a guanine nucleotide exchange factor containing an N… (More)
National Institutes of Health

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Topic mentions per year

1993-2017
051019932017

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In BloodProcess of secretionRALGDS geneRas Signaling Pathway
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Rgl3 protein, mouse

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1936-2019
19401960198020002020
ral Guanine Nucleotide Exchange Factor
standards characteristics
physiological aspects
Signal Transduction
protein protein interaction
chemical synthesis

Papers overview

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2002
2002
β-Arrestins regulate a Ral-GDS–Ral effector pathway that mediates cytoskeletal reorganization
β-Arrestins are important in chemoattractant receptor-induced granule release, a process that may involve Ral-dependent… (More)
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Highly Cited
2001
Highly Cited
2001
Signal pathways which promote invasion and metastasis: critical and distinct contributions of extracellular signal-regulated kinase and Ral-specific guanine exchange factor pathways.
Approximately 50% of metastatic tumors contain Ras mutations. Ras proteins can activate at least three downstream signaling… (More)
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2000
2000
RalGEF2, a pleckstrin homology domain containing guanine nucleotide exchange factor for Ral.
Ral is a ubiquitously expressed Ras-like small GTPase. Several guanine nucleotide exchange factors for Ral have been identified… (More)
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1999
1999
Thermodynamic and kinetic characterization of the interaction between the Ras binding domain of AF6 and members of the Ras subfamily.
Cellular signaling downstream of Ras is highly diversified and may involve many different effector molecules. A potential… (More)
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1997
1997
Colocalization of Ras and Ral on the membrane is required for Ras-dependent Ral activation through Ral GDP dissociation stimulator
Ral GDP dissociation stimulator (RalGDS), a putative effector protein of Ras, stimulated the GDP/GTP exchange reaction of the… (More)
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Highly Cited
1996
Highly Cited
1996
Differential interaction of the ras family GTP-binding proteins H-Ras, Rap1A, and R-Ras with the putative effector molecules Raf kinase and Ral-guanine nucleotide exchange factor.
The interactions of H-Ras, R-Ras, and Rap1A with the Ras-binding domains (RBD) of the c-Raf kinase and of the Ral guanine… (More)
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Highly Cited
1996
Highly Cited
1996
Ral-GTPases mediate a distinct downstream signaling pathway from Ras that facilitates cellular transformation.
Ral proteins (RalA and RalB) comprise a distinct family of Ras-related GTPases (Feig and Emkey, 1993). Recently, Ral-GDS, the… (More)
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Highly Cited
1994
Highly Cited
1994
Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap.
To identify proteins that bind to the Ras-related protein R-ras we performed a yeast two-hybrid cDNA library screen. Several… (More)
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Highly Cited
1994
Highly Cited
1994
ralGDS family members interact with the effector loop of ras p21.
Using a yeast two-hybrid system, we identified a novel protein which interacts with ras p21. This protein shares 69% amino acid… (More)
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1993
1993
Characterization of a guanine nucleotide dissociation stimulator for a ras-related GTPase.
ras-related GTPases participate in signaling for a variety of cellular processes. The GTPases cycle between a GTP-bound active… (More)
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