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ral Guanine Nucleotide Exchange Factor
Known as:
ral GDS
, RGF
, ral Guanine Nucleotide Exchange Factor [Chemical/Ingredient]
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Encoded by human RALGDS Gene, 914-aa 101-kDa RAL Guanine Nucleotide Dissociation Stimulator is a guanine nucleotide exchange factor containing an N…
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National Institutes of Health
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Related topics
Related topics
15 relations
In Blood
Process of secretion
RALGDS gene
RALGDS wt Allele
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Narrower (1)
Rgl3 protein, mouse
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2015
Highly Cited
2015
Oncogenic and RASopathy-associated K-RAS mutations relieve membrane-dependent occlusion of the effector-binding site
M. Mazhab-Jafari
,
C. Marshall
,
+6 authors
M. Ikura
Proceedings of the National Academy of Sciences
2015
Corpus ID: 39672996
Significance KRAS (Kirsten rat sarcoma viral oncogene homolog) is frequently mutated in pancreatic, colon, and lung tumors, which…
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Highly Cited
2005
Highly Cited
2005
RalGDS is required for tumor formation in a model of skin carcinogenesis.
A. González-García
,
C. Pritchard
,
H. Paterson
,
G. Mavria
,
G. Stamp
,
C. Marshall
Cancer cell
2005
Corpus ID: 27366551
Review
2002
Review
2002
Distinct requirements for Ras oncogenesis in human versus mouse cells.
N. Hamad
,
J. H. Elconin
,
+5 authors
C. Counter
Genes & development
2002
Corpus ID: 36201175
The spectrum of tumors associated with oncogenic Ras in humans often differs from those in mice either treated with carcinogens…
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Highly Cited
2002
Highly Cited
2002
β-Arrestins regulate a Ral-GDS–Ral effector pathway that mediates cytoskeletal reorganization
M. Bhattacharya
,
P. H. Anborgh
,
+7 authors
S. Ferguson
Nature Cell Biology
2002
Corpus ID: 20784208
β-Arrestins are important in chemoattractant receptor-induced granule release, a process that may involve Ral-dependent…
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Highly Cited
2001
Highly Cited
2001
Oncogenic Ras Blocks Anoikis by Activation of a Novel Effector Pathway Independent of Phosphatidylinositol 3-Kinase
A. McFall
,
Aylin S. Ülkü
,
Q. Lambert
,
A. Kusa
,
K. Rogers-Graham
,
C. Der
Molecular and Cellular Biology
2001
Corpus ID: 9838636
ABSTRACT Activated Ras, but not Raf, causes transformation of RIE-1 rat intestinal epithelial cells, demonstrating the importance…
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Highly Cited
2001
Highly Cited
2001
Signal Pathways Which Promote Invasion and Metastasis: Critical and Distinct Contributions of Extracellular Signal-Regulated Kinase and Ral-Specific Guanine Exchange Factor Pathways
Y. Ward
,
Warner W Wang
,
E. Woodhouse
,
I. Linnoila
,
L. Liotta
,
K. Kelly
Molecular and Cellular Biology
2001
Corpus ID: 1780975
ABSTRACT Approximately 50% of metastatic tumors contain Ras mutations. Ras proteins can activate at least three downstream…
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Highly Cited
1996
Highly Cited
1996
Differential Interaction of the Ras Family GTP-binding Proteins H-Ras, Rap1A, and R-Ras with the Putative Effector Molecules Raf Kinase and Ral-Guanine Nucleotide Exchange Factor
C. Herrmann
,
G. Horn
,
M. Spaargaren
,
A. Wittinghofer
The Journal of Biological Chemistry
1996
Corpus ID: 32933236
The interactions of H-Ras, R-Ras, and Rap1A with the Ras-binding domains (RBD) of the c-Raf kinase and of the Ral guanine…
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Highly Cited
1996
Highly Cited
1996
Ral‐GTPases mediate a distinct downstream signaling pathway from Ras that facilitates cellular transformation.
T. Urano
,
R. Emkey
,
L. Feig
The EMBO journal
1996
Corpus ID: 27659273
Ral proteins (RalA and RalB) comprise a distinct family of Ras‐related GTPases (Feig and Emkey, 1993). Recently, Ral‐GDS, the…
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Highly Cited
1994
Highly Cited
1994
ralGDS family members interact with the effector loop of ras p21
A. Kikuchi
,
S. Demo
,
Z. Ye
,
Y. W. Chen
,
L. Williams
Molecular and cellular biology
1994
Corpus ID: 30127588
Using a yeast two-hybrid system, we identified a novel protein which interacts with ras p21. This protein shares 69% amino acid…
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Highly Cited
1993
Highly Cited
1993
Characterization of a guanine nucleotide dissociation stimulator for a ras‐related GTPase.
C. Albright
,
B. Giddings
,
J. Liu
,
M. Vito
,
R. Weinberg
The EMBO journal
1993
Corpus ID: 6279283
ras‐related GTPases participate in signaling for a variety of cellular processes. The GTPases cycle between a GTP‐bound active…
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