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ral Guanine Nucleotide Exchange Factor

Known as: ral GDS, RGF, ral Guanine Nucleotide Exchange Factor [Chemical/Ingredient] 
Encoded by human RALGDS Gene, 914-aa 101-kDa RAL Guanine Nucleotide Dissociation Stimulator is a guanine nucleotide exchange factor containing an N… Expand
National Institutes of Health

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15 relations
In BloodProcess of secretionRALGDS geneRALGDS wt Allele
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Rgl3 protein, mouse

Papers overview

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Highly Cited
2002
Highly Cited
2002
β-Arrestins regulate a Ral-GDS–Ral effector pathway that mediates cytoskeletal reorganization
β-Arrestins are important in chemoattractant receptor-induced granule release, a process that may involve Ral-dependent… Expand
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Review
2002
Review
2002
Distinct requirements for Ras oncogenesis in human versus mouse cells.
The spectrum of tumors associated with oncogenic Ras in humans often differs from those in mice either treated with carcinogens… Expand
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2001
2001
Silencing and reactivation of the selective estrogen receptor modulator-estrogen receptor alpha complex.
4-Hydroxytamoxifen (4-OHT), a selective estrogen receptor modulator, is an agonist at a transforming growth factor-alpha (TGF… Expand
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Highly Cited
2001
Highly Cited
2001
Regulation of the Forkhead Transcription Factor AFX by Ral-Dependent Phosphorylation of Threonines 447 and 451
ABSTRACT AFX is a Forkhead transcription factor that induces a G1 cell cycle arrest via upregulation of the cell cycle inhibitor… Expand
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Highly Cited
2001
Highly Cited
2001
Signal Pathways Which Promote Invasion and Metastasis: Critical and Distinct Contributions of Extracellular Signal-Regulated Kinase and Ral-Specific Guanine Exchange Factor Pathways
ABSTRACT Approximately 50% of metastatic tumors contain Ras mutations. Ras proteins can activate at least three downstream… Expand
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Highly Cited
1999
Highly Cited
1999
Thermodynamic and Kinetic Characterization of the Interaction between the Ras Binding Domain of AF6 and Members of the Ras Subfamily*
Cellular signaling downstream of Ras is highly diversified and may involve many different effector molecules. A potential… Expand
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Highly Cited
1996
Highly Cited
1996
Differential Interaction of the Ras Family GTP-binding Proteins H-Ras, Rap1A, and R-Ras with the Putative Effector Molecules Raf Kinase and Ral-Guanine Nucleotide Exchange Factor
The interactions of H-Ras, R-Ras, and Rap1A with the Ras-binding domains (RBD) of the c-Raf kinase and of the Ral guanine… Expand
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Highly Cited
1996
Highly Cited
1996
Ral-GTPases mediate a distinct downstream signaling pathway from Ras that facilitates cellular transformation.
Ral proteins (RalA and RalB) comprise a distinct family of Ras-related GTPases (Feig and Emkey, 1993). Recently, Ral-GDS, the… Expand
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Highly Cited
1994
Highly Cited
1994
Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap.
To identify proteins that bind to the Ras-related protein R-ras we performed a yeast two-hybrid cDNA library screen. Several… Expand
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Highly Cited
1993
Highly Cited
1993
Characterization of a guanine nucleotide dissociation stimulator for a ras-related GTPase.
ras-related GTPases participate in signaling for a variety of cellular processes. The GTPases cycle between a GTP-bound active… Expand
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