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quinine 3-monooxygenase activity

Known as: nifedipine oxidase activity, quinine 3-hydroxylase activity, quinine,NADPH:oxygen oxidoreductase activity 
Catalysis of the reaction: H(+) + NADPH + O(2) + quinine = 3-hydroxyquinine + H(2)O + NADP(+). [EC:1.14.13.67, RHEA:20152]
National Institutes of Health

Papers overview

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2019
2019
Study on the inhibitory effect of furafylline and troleandomycin in the 7‐methoxyresorufin‐O‐demethylase and nifedipine oxidase activities in hepatic microsomes from four poultry species using high…
2004
2004
Presence of cytochrome P450 enzymes in human CD34+ haematopoietic progenitor cells.
Human CD34+ cells (haematopoietic stem and progenitor cells separated from peripheral blood) were shown to express CYP2E1 protein… 
2004
2004
Drug-Drug Interactions Evaluated by a Highly Active Reconstituted Native Human Cytochrome P4503A4 and Human NADPH-Cytochrome P450 Reductase System
Summary Catalytic activities of native human CYP3A4-mediated reactions as well as drug interactions were directly evaluated by… 
2000
2000
A POTENT INHIBITOR OF BOTH P-GLYCOPROTEIN AND CYP 3 A IN VITRO
Mibefradil, a calcium Tand L-channel blocker developed for use in hypertension, was recently removed from the market after… 
1999
1999
Use of the steroid derivative RPR 106541 in combination with site-directed mutagenesis for enhanced cytochrome P-450 3A4 structure/function analysis.
RPR 106541 (20R-16alpha,17alpha-[butylidenebis(oxy)]-6al pha, 9alpha-difluoro-11beta-hydroxy-17beta-(methylthio)androst a-4-en-3… 
1999
1999
Investigations on the Role of Cytochrome b5 and Divalent Cations in the Maximal Nifedipine Oxidase Activity of Human Liver
Summary Native human cytochrome P4503A4 was most active in nifedipine oxidation when incorporated into a binary phospholipid… 
1998
1998
Ipriflavone as an inhibitor of human cytochrome P450 enzymes
Reduction of theophylline metabolism and elimination were observed in a theophylline‐treated patient during ipriflavone… 
Highly Cited
1997
Highly Cited
1997
The In vitro hepatic metabolism of quinine in mice, rats and dogs: comparison with human liver microsomes.
The major metabolic pathway of quinine in the human has been shown to be 3-hydroxylation mediated mainly by human cytochrome P450… 
Highly Cited
1989
Highly Cited
1989
Characterization of mRNA species related to human liver cytochrome P-450 nifedipine oxidase and the regulation of catalytic activity.
P-450NF is the major enzyme in human liver involved in the metabolism of the calcium-channel blocker nifedipine. By screening a… 
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