quinine 3-monooxygenase activity

Known as: nifedipine oxidase activity, quinine 3-hydroxylase activity, quinine,NADPH:oxygen oxidoreductase activity 
Catalysis of the reaction: H(+) + NADPH + O(2) + quinine = 3-hydroxyquinine + H(2)O + NADP(+). [EC:1.14.13.67, RHEA:20152]
National Institutes of Health

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Topic mentions per year

1986-2004
02419862004

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Highly Cited
2002
Highly Cited
2002
Ketamine is a widely used drug for its anesthetic and analgesic properties; it is also considered as a drug of abuse, as many… (More)
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2000
2000
Mibefradil, a calcium T- and L-channel blocker developed for use in hypertension, was recently removed from the market after… (More)
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Highly Cited
1998
Highly Cited
1998
Cytochrome P450 (CYP) of the 3A family (CYP3A) has been detected in minipig liver microsomes by immunochemical screening (Western… (More)
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1998
1998
1. The metabolism of Meloxicam (ME) and the cytochrome(s) P450 (CYPs) involved were analysed by using primary human hepatocytes… (More)
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1994
1994
The oxidative metabolism of FK506 by liver microsomes and purified cytochrome P450 (P450) enzymes from rats, dogs and humans was… (More)
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Highly Cited
1989
Highly Cited
1989
In vitro studies with human liver indicate that the major catalyst involved in the bioactivation of the hepato-carcinogen… (More)
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1989
1989
P-450NF is the major enzyme in human liver involved in the metabolism of the calcium-channel blocker nifedipine. By screening a… (More)
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Highly Cited
1988
Highly Cited
1988
Cytochrome P-450-dependent steroid hormone metabolism was studied in isolated human liver microsomal fractions. 6 beta… (More)
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1988
1988
P450PCN protein levels and nifedipine oxidase activities were quantitated in 12 human livers and were shown to be highly… (More)
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Highly Cited
1986
Highly Cited
1986
The metabolism of the dihydropyridine calcium antagonist and vasodilator nifedipine has been reported to exhibit polymorphism… (More)
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