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quinine 3-monooxygenase activity

Known as: nifedipine oxidase activity, quinine 3-hydroxylase activity, quinine,NADPH:oxygen oxidoreductase activity 
Catalysis of the reaction: H(+) + NADPH + O(2) + quinine = 3-hydroxyquinine + H(2)O + NADP(+). [EC:1.14.13.67, RHEA:20152]
National Institutes of Health

Papers overview

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Highly Cited
2002
Highly Cited
2002
Ketamine is a widely used drug for its anesthetic and analgesic properties; it is also considered as a drug of abuse, as many… 
Highly Cited
1998
Highly Cited
1998
Cytochrome P450 (CYP) of the 3A family (CYP3A) has been detected in minipig liver microsomes by immunochemical screening (Western… 
Highly Cited
1998
Highly Cited
1998
1. The metabolism of Meloxicam (ME) and the cytochrome(s) P450 (CYPs) involved were analysed by using primary human hepatocytes… 
Highly Cited
1989
Highly Cited
1989
In vitro studies with human liver indicate that the major catalyst involved in the bioactivation of the hepato-carcinogen… 
Highly Cited
1989
Highly Cited
1989
P-450NF is the major enzyme in human liver involved in the metabolism of the calcium-channel blocker nifedipine. By screening a… 
Highly Cited
1988
Highly Cited
1988
P450PCN protein levels and nifedipine oxidase activities were quantitated in 12 human livers and were shown to be highly… 
Highly Cited
1986
Highly Cited
1986
The metabolism of the dihydropyridine calcium antagonist and vasodilator nifedipine has been reported to exhibit polymorphism…