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quinine 3-monooxygenase activity
Known as:
nifedipine oxidase activity
, quinine 3-hydroxylase activity
, quinine,NADPH:oxygen oxidoreductase activity
Catalysis of the reaction: H(+) + NADPH + O(2) + quinine = 3-hydroxyquinine + H(2)O + NADP(+). [EC:1.14.13.67, RHEA:20152]
National Institutes of Health
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Highly Cited
2002
Highly Cited
2002
Contribution of CYP3A4, CYP2B6, and CYP2C9 isoforms to N-demethylation of ketamine in human liver microsomes.
Y. Hijazi
,
R. Boulieu
Drug Metabolism And Disposition
2002
Corpus ID: 15787750
Ketamine is a widely used drug for its anesthetic and analgesic properties; it is also considered as a drug of abuse, as many…
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Highly Cited
1998
Highly Cited
1998
Presence and activity of cytochrome P450 isoforms in minipig liver microsomes. Comparison with human liver samples.
P. Anzenbacher
,
P. Souček
,
+4 authors
J. Kvetina
Drug Metabolism And Disposition
1998
Corpus ID: 8330217
Cytochrome P450 (CYP) of the 3A family (CYP3A) has been detected in minipig liver microsomes by immunochemical screening (Western…
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Highly Cited
1998
Highly Cited
1998
Metabolism of Meloxicam in human liver involves cytochromes P4502C9 and 3A4.
C. Chesné
,
C. Guyomard
,
A. Guillouzo
,
J. Schmid
,
E. Ludwig
,
T. Sauter
Xenobiotica; the fate of foreign compounds in…
1998
Corpus ID: 22489416
1. The metabolism of Meloxicam (ME) and the cytochrome(s) P450 (CYPs) involved were analysed by using primary human hepatocytes…
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Highly Cited
1997
Highly Cited
1997
Colchicine biotransformation by human liver microsomes. Identification of CYP3A4 as the major isoform responsible for colchicine demethylation.
T. Tateishi
,
P. Souček
,
Y. Caraco
,
F. Guengerich
,
A. Wood
Biochemical Pharmacology
1997
Corpus ID: 31812278
Highly Cited
1994
Highly Cited
1994
Metabolism of FK506, a potent immunosuppressive agent, by cytochrome P450 3A enzymes in rat, dog and human liver microsomes.
T. Shiraga
,
H. Matsuda
,
+5 authors
Y. Funae
Biochemical Pharmacology
1994
Corpus ID: 25283574
Highly Cited
1989
Highly Cited
1989
Evidence for cytochrome P-450NF, the nifedipine oxidase, being the principal enzyme involved in the bioactivation of aflatoxins in human liver.
T. Shimada
,
F. Guengerich
Proceedings of the National Academy of Sciences…
1989
Corpus ID: 43187110
In vitro studies with human liver indicate that the major catalyst involved in the bioactivation of the hepato-carcinogen…
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Highly Cited
1989
Highly Cited
1989
Characterization of mRNA species related to human liver cytochrome P-450 nifedipine oxidase and the regulation of catalytic activity.
R. W. Bork
,
T. Muto
,
P. Beaune
,
P. Srivastava
,
R. Lloyd
,
F. Guengerich
Journal of Biological Chemistry
1989
Corpus ID: 21034857
P-450NF is the major enzyme in human liver involved in the metabolism of the calcium-channel blocker nifedipine. By screening a…
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Highly Cited
1988
Highly Cited
1988
Human liver microsomal steroid metabolism: identification of the major microsomal steroid hormone 6 beta-hydroxylase cytochrome P-450 enzyme.
D. Waxman
,
C. Attisano
,
F. Guengerich
,
D. Lapenson
Archives of Biochemistry and Biophysics
1988
Corpus ID: 43658661
Highly Cited
1988
Highly Cited
1988
Human P450PCN1: sequence, chromosome localization, and direct evidence through cDNA expression that P450PCN1 is nifedipine oxidase.
F. Gonzalez
,
B. J. Schmid
,
+5 authors
J. Idle
DNA
1988
Corpus ID: 45514137
P450PCN protein levels and nifedipine oxidase activities were quantitated in 12 human livers and were shown to be highly…
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Highly Cited
1986
Highly Cited
1986
Characterization of rat and human liver microsomal cytochrome P-450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism.
F. Guengerich
,
M. Martín
,
P. Beaune
,
P. Kremers
,
T. Wolff
,
D. Waxman
Journal of Biological Chemistry
1986
Corpus ID: 5570007
The metabolism of the dihydropyridine calcium antagonist and vasodilator nifedipine has been reported to exhibit polymorphism…
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