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quinine 3-monooxygenase activity

Known as: nifedipine oxidase activity, quinine 3-hydroxylase activity, quinine,NADPH:oxygen oxidoreductase activity 
Catalysis of the reaction: H(+) + NADPH + O(2) + quinine = 3-hydroxyquinine + H(2)O + NADP(+). [EC:1.14.13.67, RHEA:20152]
National Institutes of Health

Papers overview

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Highly Cited
2002
Highly Cited
2002
Contribution of CYP3A4, CYP2B6, and CYP2C9 isoforms to N-demethylation of ketamine in human liver microsomes.
Ketamine is a widely used drug for its anesthetic and analgesic properties; it is also considered as a drug of abuse, as many… 
Highly Cited
1998
Highly Cited
1998
Presence and activity of cytochrome P450 isoforms in minipig liver microsomes. Comparison with human liver samples.
Cytochrome P450 (CYP) of the 3A family (CYP3A) has been detected in minipig liver microsomes by immunochemical screening (Western… 
Highly Cited
1998
Highly Cited
1998
Metabolism of Meloxicam in human liver involves cytochromes P4502C9 and 3A4.
1. The metabolism of Meloxicam (ME) and the cytochrome(s) P450 (CYPs) involved were analysed by using primary human hepatocytes… 
Highly Cited
1997
Highly Cited
1997
Colchicine biotransformation by human liver microsomes. Identification of CYP3A4 as the major isoform responsible for colchicine demethylation.
Highly Cited
1994
Highly Cited
1994
Metabolism of FK506, a potent immunosuppressive agent, by cytochrome P450 3A enzymes in rat, dog and human liver microsomes.
Highly Cited
1989
Highly Cited
1989
Evidence for cytochrome P-450NF, the nifedipine oxidase, being the principal enzyme involved in the bioactivation of aflatoxins in human liver.
In vitro studies with human liver indicate that the major catalyst involved in the bioactivation of the hepato-carcinogen… 
Highly Cited
1989
Highly Cited
1989
Characterization of mRNA species related to human liver cytochrome P-450 nifedipine oxidase and the regulation of catalytic activity.
P-450NF is the major enzyme in human liver involved in the metabolism of the calcium-channel blocker nifedipine. By screening a… 
Highly Cited
1988
Highly Cited
1988
Human liver microsomal steroid metabolism: identification of the major microsomal steroid hormone 6 beta-hydroxylase cytochrome P-450 enzyme.
Highly Cited
1988
Highly Cited
1988
Human P450PCN1: sequence, chromosome localization, and direct evidence through cDNA expression that P450PCN1 is nifedipine oxidase.
P450PCN protein levels and nifedipine oxidase activities were quantitated in 12 human livers and were shown to be highly… 
Highly Cited
1986
Highly Cited
1986
Characterization of rat and human liver microsomal cytochrome P-450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism.
The metabolism of the dihydropyridine calcium antagonist and vasodilator nifedipine has been reported to exhibit polymorphism… 
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