pyruvate dehydrogenase (acetyl-transferring) kinase activity

Known as: PDH kinase activity, [pyruvate dehydrogenase (lipoamide)] kinase activity, ATP:pyruvate dehydrogenase (acetyl-transferring) phosphotransferase activity 
Catalysis of the reaction: ATP + pyruvate dehydrogenase (acetyl-transferring) = ADP + pyruvate dehydrogenase (acetyl-transferring) phosphate. [EC:2.7… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1974-2018
05010019742018

Papers overview

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Highly Cited
2012
Highly Cited
2012
DNA methylation is a covalent biochemical modification controlling chromatin structure and gene expression. Exercise elicits gene… (More)
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Highly Cited
2007
Highly Cited
2007
The unique metabolic profile of cancer (aerobic glycolysis) might confer apoptosis resistance and be therapeutically targeted… (More)
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Highly Cited
2006
Highly Cited
2006
Mammalian target of rapamycin (mTOR) controls cell growth and proliferation via the raptor-mTOR (TORC1) and rictor-mTOR (TORC2… (More)
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Highly Cited
2002
Highly Cited
2002
Pyruvate dehydrogenase kinase (PDK) catalyzes phosphorylation and inactivation of the pyruvate dehydrogenase complex (PDC). Two… (More)
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Highly Cited
2000
Highly Cited
2000
Exercise training elicits a number of adaptive changes in skeletal muscle that result in an improved metabolic efficiency. The… (More)
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Highly Cited
2000
Highly Cited
2000
In using Western blot analysis with antibodies raised against recombinant pyruvate dehydrogenase kinase (PDK) isoforms PDK2 and… (More)
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Highly Cited
1999
Highly Cited
1999
The PtdIns(3,4,5)P3-dependent activation of protein kinase B (PKB) by 3-phosphoinositide-dependent protein kinases-1 and -2 (PDK1… (More)
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Highly Cited
1998
Highly Cited
1998
Tissue distribution and kinetic parameters for the four isoenzymes of pyruvate dehydrogenase kinase (PDK1, PDK2, PDK3 and PDK4… (More)
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Highly Cited
1998
Highly Cited
1998
This study investigated whether conditions known to alter the activity and phosphorylation state of the pyruvate dehydrogenase… (More)
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Highly Cited
1998
Highly Cited
1998
BACKGROUND The p70 S6 kinase, an enzyme critical for cell-cycle progression through the G1 phase, is activated in vivo by insulin… (More)
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