pyrrolopyrimidine

 
National Institutes of Health

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Highly Cited
2012
Highly Cited
2012
AKT is a key node in the most frequently deregulated signaling network in human cancer. AZD5363, a novel pyrrolopyrimidine… (More)
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2011
2011
There is considerable interest in developing non-peptidic, small-molecule α-helix mimetics to disrupt α-helix-mediated protein… (More)
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Highly Cited
2010
Highly Cited
2010
There is a critical need for safer and more convenient treatments for organ transplant rejection and autoimmune disorders such as… (More)
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2010
2010
The discovery and optimization of a series of pyrrolopyrimidine based protein kinase B (Pkb/Akt) inhibitors discovered via HTS… (More)
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2008
2008
Pyrrolopyrimidine nucleosides analogs, collectively referred to as deazapurines, are an important class of structurally diverse… (More)
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2007
2007
A new class of bicyclic pyrrolopyrimidine-based Janus kinase 3 (JAK-3) inhibitors are described. Many of these inhibitors showed… (More)
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2003
2003
Two bona fide c-Src inhibitors, denominated CGP77675 and CGP76030, reduced in a time- and concentration-dependent manner (i) the… (More)
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2003
2003
Three new pyrrolopyrimidine alkaloids, rigidins B-D (1-3), have been isolated from an Okinawan marine tunicate Cystodytes sp… (More)
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Highly Cited
1998
Highly Cited
1998
Extensive biochemical and pharmacological evidence indicates that LY231514 is a novel antifolate antimetabolite. LY231514 is… (More)
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Highly Cited
1996