Skip to search formSkip to main contentSkip to account menu

pyrrolopyrimidine

National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

PyrimidinesPyrroles

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Overcoming Resistance to AC0010, a Third Generation of EGFR Inhibitor, by Targeting c-MET and BCL-2
2012
2012
Structure-based design of 2,6,7-trisubstituted-7H-pyrrolo[2,3-d]pyrimidines as Aurora kinases inhibitors.
Highly Cited
2010
Highly Cited
2010
Polarizable water molecules in ligand-macromolecule recognition. Impact on the relative affinities of competing pyrrolopyrimidine inhibitors for FAK kinase.
Using polarizable molecular mechanics (PMM), we have compared the complexation energies of the focal adhesion kinase (FAK) kinase… 
2008
2008
Discovery of selective and nonpeptidic cathepsin S inhibitors.
Highly Cited
2005
Highly Cited
2005
Structure-based design of novel Chk1 inhibitors: insights into hydrogen bonding and protein-ligand affinity.
We report the discovery, synthesis, and crystallographic binding mode of novel furanopyrimidine and pyrrolopyrimidine inhibitors… 
2004
2004
Design and synthesis of new templates derived from pyrrolopyrimidine as selective multidrug-resistance-associated protein inhibitors in multidrug resistance.
In our continued effort to identify selective MRP1 modulators, we have developed two novel templates, 3 and 4, through rational… 
2003
2003
tRNA-guanine transglycosylase from E. coli: a ping-pong kinetic mechanism is consistent with nucleophilic catalysis.
1999
1999
Neuroprotective efficacy of combination therapy with two different antioxidants in rats subjected to transient focal ischemia
Highly Cited
1977
Highly Cited
1977
Failure to elicit conditioned taste aversion by severe poisoning
1969
1969
Nucleoside antibiotics. IV. Metabolic fate of adenosine and cordycepin by Cordyceps militaris during cordycepin biosynthesis.
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)