pyrimidin-2-one beta-ribofuranoside

Known as: pyrimidin-2-one beta-D-ribofuranoside, Zebularine, 2-Pyrimidone-1-beta-D-riboside 
A synthetic cytidine analogue and a cytidine deaminase inhibitor with anticancer activity. Following metabolic activation by phosphorylation and… (More)
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
The three DNA methyltransferase (DNMT)-inhibiting cytosine nucleoside analogues, azacitidine, decitabine and zebularine, which… (More)
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Highly Cited
2008
Highly Cited
2008
Long-term memory formation requires selective changes in gene expression. Here, we determined the contribution of chromatin… (More)
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Highly Cited
2006
Highly Cited
2006
BACKGROUND & AIMS Although the natural history and pathologic characteristics of human hepatocellular carcinoma (HCC) are well… (More)
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Highly Cited
2006
Highly Cited
2006
DNA (cytosine-5) methylation represents one of the most widely used mechanisms of enduring cellular memory. Stable patterns of… (More)
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Highly Cited
2006
Highly Cited
2006
DNA methyltransferase inhibitors represent promising new drugs for cancer therapies. The first of these compounds (5-azacytidine… (More)
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Highly Cited
2005
Highly Cited
2005
A strong association exists between states of chronic inflammation and cancer, and it is believed that mediators of inflammation… (More)
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Highly Cited
2004
Highly Cited
2004
The frequent silencing of tumor suppressor genes by altered cytosine methylation and chromatin structural changes makes this… (More)
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Highly Cited
2004
Highly Cited
2004
During tumorigenesis, tumor suppressor and cancer-related genes are commonly silenced by aberrant DNA methylation in their… (More)
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Highly Cited
2003
Highly Cited
2003
BACKGROUND Gene silencing by abnormal methylation of promoter regions of regulatory genes is commonly associated with cancer… (More)
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Highly Cited
2002
Highly Cited
2002
Mechanism-based inhibitors of enzymes, which mimic reactive intermediates in the reaction pathway, have been deployed extensively… (More)
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