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pyrimidin-2-one beta-ribofuranoside
Known as:
pyrimidin-2-one beta-D-ribofuranoside
, Zebularine
, 2-Pyrimidone-1-beta-D-riboside
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A synthetic cytidine analogue and a cytidine deaminase inhibitor with anticancer activity. Following metabolic activation by phosphorylation and…
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National Institutes of Health
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Related topics
Related topics
4 relations
Broader (1)
Cytidine
NCIt Antineoplastic Agent Terminology
analogs & derivatives
Narrower (1)
NSC 309132
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
Reactivation of the silenced thyroid hormone receptor β gene expression delays thyroid tumor progression.
Won Gu Kim
,
Xuguang Zhu
,
D. W. Kim
,
Lisa Zhang
,
E. Kebebew
,
Sheue-yann Cheng
Endocrinology
2013
Corpus ID: 27398858
That a knock-in mouse harboring a dominant-negative thyroid hormone receptor (TR)-β (Thrb) mutation develops metastatic thyroid…
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2013
2013
The DNA methyltransferase inhibitor zebularine induces mitochondria-mediated apoptosis in gastric cancer cells in vitro and in vivo.
W. Tan
,
W. Zhou
,
Hong-gang Yu
,
He-sheng Luo
,
Lei Shen
Biochemical and Biophysical Research…
2013
Corpus ID: 25001399
2011
2011
Insights Into Mutagenesis Using Escherichia coli Chromosomal lacZ Strains That Enable Detection of a Wide Spectrum of Mutational Events
Tracey Seier
,
Dana R Padgett
,
Gal Zilberberg
,
V. Sutera
,
N. Toha
,
S. Lovett
Genetics
2011
Corpus ID: 22005253
Strand misalignments at DNA repeats during replication are implicated in mutational hotspots. To study these events, we have…
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Highly Cited
2010
Highly Cited
2010
An Integrated Genomic and Epigenomic Approach Predicts Therapeutic Response to Zebularine in Human Liver Cancer
J. Andersen
,
V. Factor
,
+5 authors
S. Thorgeirsson
Science Translational Medicine
2010
Corpus ID: 11659269
Drug-induced transcription and epigenetic changes can predict whether liver cancer can be successfully treated with an epigenome…
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2008
2008
Promoter analysis of epigenetically controlled genes in bladder cancer
Srinivas Veerla
,
I. Panagopoulos
,
Yuesheng Jin
,
David Lindgren
,
M. Höglund
Genes, Chromosomes and Cancer
2008
Corpus ID: 11686401
DNA methylation is an important epigenetic modification that regulates several genes crucial for tumor development. To identify…
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2005
2005
Origin of tight binding of a near-perfect transition-state analogue by cytidine deaminase: implications for enzyme catalysis.
Hao-Bo Guo
,
Niny Z. Rao
,
Qin Xu
,
Hong Guo
Journal of the American Chemical Society
2005
Corpus ID: 20509846
Cytidine deaminase (CDA) is a zinc metalloenzyme that catalyzes the hydrolytic deamination of cytidine to uridine. Zebularine…
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Highly Cited
1996
Highly Cited
1996
Cytidine deaminase complexed to 3-deazacytidine: a "valence buffer" in zinc enzyme catalysis.
S. Xiang
,
S. A. Short
,
R. Wolfenden
,
C. Carter
Biochemistry
1996
Corpus ID: 23789057
The cytidine deaminase substrate analog inhibitor 3-deazacytidine binds with its 4-amino group inserted into a site previously…
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Highly Cited
1991
Highly Cited
1991
Antitumor properties of 2(1H)-pyrimidinone riboside (zebularine) and its fluorinated analogues.
J. Driscoll
,
V. Marquez
,
J. Plowman
,
P. S. Liu
,
J. Kelley
,
J. Barchi
Journal of Medicinal Chemistry
1991
Corpus ID: 5621587
2(1H)-Pyrimidinone riboside (zebularine, 1b) and its 5-fluoro (6b) and 2'-ara-fluoro (7b) analogues have been synthesized and…
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Highly Cited
1989
Highly Cited
1989
Binding of pyrimidin-2-one ribonucleoside by cytidine deaminase as the transition-state analogue 3,4-dihydrouridine and the contribution of the 4-hydroxyl group to its binding affinity.
L. Frick
,
C. Yang
,
V. Marquez
,
R. Wolfenden
Biochemistry
1989
Corpus ID: 1784693
Cytidine deaminase, purified to homogeneity from constitutive mutants of Escherichia coli, was found to bind the competitive…
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1972
1972
Codon-anticodon interaction studied with oligonucleotides containing 3 -deazauridine, 4 -deoxyuridine or 3 -deaza- 4 -deoxyuridine. I. Synthesis by primer-dependent polynucleotide phosphorylase of…
H. Schetters
,
H. Gassen
,
H. Matthaei
Biochimica et Biophysica Acta
1972
Corpus ID: 31719988
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