pyrimidin-2-one beta-ribofuranoside

Known as: pyrimidin-2-one beta-D-ribofuranoside, Zebularine, 2-Pyrimidone-1-beta-D-riboside 
A synthetic cytidine analogue and a cytidine deaminase inhibitor with anticancer activity. Following metabolic activation by phosphorylation and… (More)
National Institutes of Health

Related topics

Related topics

3 relations

Broader (1)

Cytidine

Narrower (1)

NSC 309132
analogs & derivatives

Papers overview

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Highly Cited
2009
Highly Cited
2009
The DNA methyltransferase inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute myeloid leukemia cells
The three DNA methyltransferase (DNMT)-inhibiting cytosine nucleoside analogues, azacitidine, decitabine and zebularine, which… (More)
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Highly Cited
2008
Highly Cited
2008
Epigenetic regulation of BDNF gene transcription in the consolidation of fear memory.
Long-term memory formation requires selective changes in gene expression. Here, we determined the contribution of chromatin… (More)
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Highly Cited
2006
Highly Cited
2006
Ubiquitous activation of Ras and Jak/Stat pathways in human HCC.
BACKGROUND & AIMS Although the natural history and pathologic characteristics of human hepatocellular carcinoma (HCC) are well… (More)
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Highly Cited
2006
Highly Cited
2006
Evidence that DNA (cytosine-5) methyltransferase regulates synaptic plasticity in the hippocampus.
DNA (cytosine-5) methylation represents one of the most widely used mechanisms of enduring cellular memory. Stable patterns of… (More)
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Highly Cited
2006
Highly Cited
2006
Functional diversity of DNA methyltransferase inhibitors in human cancer cell lines.
DNA methyltransferase inhibitors represent promising new drugs for cancer therapies. The first of these compounds (5-azacytidine… (More)
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Highly Cited
2005
Highly Cited
2005
Interleukin 6 supports the maintenance of p53 tumor suppressor gene promoter methylation.
A strong association exists between states of chronic inflammation and cancer, and it is believed that mediators of inflammation… (More)
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Highly Cited
2004
Highly Cited
2004
Preferential response of cancer cells to zebularine.
The frequent silencing of tumor suppressor genes by altered cytosine methylation and chromatin structural changes makes this… (More)
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Highly Cited
2004
Highly Cited
2004
Continuous zebularine treatment effectively sustains demethylation in human bladder cancer cells.
During tumorigenesis, tumor suppressor and cancer-related genes are commonly silenced by aberrant DNA methylation in their… (More)
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Highly Cited
2003
Highly Cited
2003
Inhibition of DNA methylation and reactivation of silenced genes by zebularine.
BACKGROUND Gene silencing by abnormal methylation of promoter regions of regulatory genes is commonly associated with cancer… (More)
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Highly Cited
2002
Highly Cited
2002
Zebularine: a novel DNA methylation inhibitor that forms a covalent complex with DNA methyltransferases.
Mechanism-based inhibitors of enzymes, which mimic reactive intermediates in the reaction pathway, have been deployed extensively… (More)
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