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pyrimidin-2-one beta-ribofuranoside

Known as: pyrimidin-2-one beta-D-ribofuranoside, Zebularine, 2-Pyrimidone-1-beta-D-riboside 
A synthetic cytidine analogue and a cytidine deaminase inhibitor with anticancer activity. Following metabolic activation by phosphorylation and… 
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
That a knock-in mouse harboring a dominant-negative thyroid hormone receptor (TR)-β (Thrb) mutation develops metastatic thyroid… 
2011
2011
Strand misalignments at DNA repeats during replication are implicated in mutational hotspots. To study these events, we have… 
Highly Cited
2010
Highly Cited
2010
Drug-induced transcription and epigenetic changes can predict whether liver cancer can be successfully treated with an epigenome… 
2008
2008
DNA methylation is an important epigenetic modification that regulates several genes crucial for tumor development. To identify… 
2005
2005
Cytidine deaminase (CDA) is a zinc metalloenzyme that catalyzes the hydrolytic deamination of cytidine to uridine. Zebularine… 
Highly Cited
1996
Highly Cited
1996
The cytidine deaminase substrate analog inhibitor 3-deazacytidine binds with its 4-amino group inserted into a site previously… 
Highly Cited
1991
Highly Cited
1991
2(1H)-Pyrimidinone riboside (zebularine, 1b) and its 5-fluoro (6b) and 2'-ara-fluoro (7b) analogues have been synthesized and… 
Highly Cited
1989
Highly Cited
1989
Cytidine deaminase, purified to homogeneity from constitutive mutants of Escherichia coli, was found to bind the competitive…