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pyrimidin-2-one beta-ribofuranoside

Known as: pyrimidin-2-one beta-D-ribofuranoside, Zebularine, 2-Pyrimidone-1-beta-D-riboside 
A synthetic cytidine analogue and a cytidine deaminase inhibitor with anticancer activity. Following metabolic activation by phosphorylation and… 
National Institutes of Health

Related topics

Related topics

4 relations

Broader (1)

Cytidine
NCIt Antineoplastic Agent Terminologyanalogs & derivatives

Narrower (1)

NSC 309132

Papers overview

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Highly Cited
2013
Highly Cited
2013
Reactivation of the silenced thyroid hormone receptor β gene expression delays thyroid tumor progression.
That a knock-in mouse harboring a dominant-negative thyroid hormone receptor (TR)-β (Thrb) mutation develops metastatic thyroid… 
2013
2013
The DNA methyltransferase inhibitor zebularine induces mitochondria-mediated apoptosis in gastric cancer cells in vitro and in vivo.
2011
2011
Insights Into Mutagenesis Using Escherichia coli Chromosomal lacZ Strains That Enable Detection of a Wide Spectrum of Mutational Events
Strand misalignments at DNA repeats during replication are implicated in mutational hotspots. To study these events, we have… 
Highly Cited
2010
Highly Cited
2010
An Integrated Genomic and Epigenomic Approach Predicts Therapeutic Response to Zebularine in Human Liver Cancer
Drug-induced transcription and epigenetic changes can predict whether liver cancer can be successfully treated with an epigenome… 
2008
2008
Promoter analysis of epigenetically controlled genes in bladder cancer
DNA methylation is an important epigenetic modification that regulates several genes crucial for tumor development. To identify… 
2005
2005
Origin of tight binding of a near-perfect transition-state analogue by cytidine deaminase: implications for enzyme catalysis.
Cytidine deaminase (CDA) is a zinc metalloenzyme that catalyzes the hydrolytic deamination of cytidine to uridine. Zebularine… 
Highly Cited
1996
Highly Cited
1996
Cytidine deaminase complexed to 3-deazacytidine: a "valence buffer" in zinc enzyme catalysis.
The cytidine deaminase substrate analog inhibitor 3-deazacytidine binds with its 4-amino group inserted into a site previously… 
Highly Cited
1991
Highly Cited
1991
Antitumor properties of 2(1H)-pyrimidinone riboside (zebularine) and its fluorinated analogues.
2(1H)-Pyrimidinone riboside (zebularine, 1b) and its 5-fluoro (6b) and 2'-ara-fluoro (7b) analogues have been synthesized and… 
Highly Cited
1989
Highly Cited
1989
Binding of pyrimidin-2-one ribonucleoside by cytidine deaminase as the transition-state analogue 3,4-dihydrouridine and the contribution of the 4-hydroxyl group to its binding affinity.
Cytidine deaminase, purified to homogeneity from constitutive mutants of Escherichia coli, was found to bind the competitive… 
1972
1972
Codon-anticodon interaction studied with oligonucleotides containing 3 -deazauridine, 4 -deoxyuridine or 3 -deaza- 4 -deoxyuridine. I. Synthesis by primer-dependent polynucleotide phosphorylase of…
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