proto-oncogene protein Spi-1

Known as: 31 kDa-Transforming Protein, SPI1, SPI1 Protein 
Transcription factor PU.1 (270 aa, ~31 kDa) is encoded by the human SPI1 gene. This protein plays a role in transcriptional regulation in… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1990-2017
010203019902017

Papers overview

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Highly Cited
2010
Highly Cited
2010
The mammalian innate immune system uses Toll-like receptors (TLRs) and Nod-LRRs (NLRs) to detect microbial components during… (More)
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Highly Cited
2010
Highly Cited
2010
CD4+ helper T cells acquire effector phenotypes that promote specialized inflammatory responses. We show that the ETS-family… (More)
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Highly Cited
2009
Highly Cited
2009
Allergic asthma is an inflammatory disease of the lung characterized by abnormal T helper-2 (T(H)2) lymphocyte responses to… (More)
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Highly Cited
2004
Highly Cited
2004
Transcription factors are believed to have a dominant role in acute myeloid leukemia (AML). This idea is supported by analysis of… (More)
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Highly Cited
2000
Highly Cited
2000
The ets family transcription factor PU.1 is required for the development of multiple lineages of the immune system. Using… (More)
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Highly Cited
2000
Highly Cited
2000
The GATA-1 transcription factor is capable of suppressing the myeloid gene expression program when ectopically expressed in… (More)
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Highly Cited
1999
Highly Cited
1999
The process through which multipotential hematopoietic cells commit to distinct lineages involves the induction of specific… (More)
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Highly Cited
1996
Highly Cited
1996
During infection of their hosts, salmonellae enter intestinal epithelial cells. It has been proposed that when Salmonella… (More)
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Highly Cited
1994
Highly Cited
1994
The transcription factor PU.1 is a hematopoietic-specific member of the ets family. Mice carrying a mutation in the PU.1 locus… (More)
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Highly Cited
1990
Highly Cited
1990
We have isolated a cDNA clone, PU.1, that codes for a new tissue-specific DNA binding protein. Analysis of the binding site by… (More)
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