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proteoglycan catabolic process

Known as: proteoglycan breakdown, proteoglycan catabolism, proteoglycan degradation 
The chemical reactions and pathways resulting in the breakdown of proteoglycans, any glycoprotein in which the carbohydrate units are… Expand
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
OBJECTIVE Traumatic joint injury can damage cartilage and release inflammatory cytokines from adjacent joint tissue. The present… Expand
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Highly Cited
2006
Highly Cited
2006
Intervertebral disc degeneration occurs commonly and is linked to persistent back pain and the development of disc herniation… Expand
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Highly Cited
2004
Highly Cited
2004
OBJECTIVE Aggrecan is degraded by Aggrecanases (ADAMTS-4 and -5) and MMPs, which cleave its core protein at different sites… Expand
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Highly Cited
2002
Highly Cited
2002
OBJECTIVE To examine cyclooxygenase-2 (COX-2) enzyme expression, its regulation by interleukin-1 beta (IL-1 beta), and the role… Expand
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Highly Cited
1998
Highly Cited
1998
OBJECTIVE To evaluate the relationship between specific cleavage of aggrecan at the Glu373-Ala374 'aggrecanase' site and… Expand
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Highly Cited
1995
Highly Cited
1995
Monoclonal antibodies have been prepared that react specifically with the neoepitopes present on proteoglycan degradation… Expand
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Highly Cited
1993
Highly Cited
1993
OBJECTIVE To investigate mechanisms of cartilage matrix destruction by a study of the effects of a specific inactivator of… Expand
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Highly Cited
1993
Highly Cited
1993
The modulation of interleukin 1 (IL-1) effects on proteoglycan metabolism in intact murine patellar cartilage by transforming… Expand
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Highly Cited
1989
Highly Cited
1989
Exposure of bovine nasal cartilage in culture to interleukin-1 (IL-1) leads to a time- and concentration-dependent stimulation of… Expand
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Highly Cited
1984
Highly Cited
1984
Homogeneous catabolin from pig leucocytes induced proteoglycan breakdown, but not collagen breakdown, in explants of articular… Expand
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