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proteoglycan catabolic process

Known as: proteoglycan breakdown, proteoglycan catabolism, proteoglycan degradation 
The chemical reactions and pathways resulting in the breakdown of proteoglycans, any glycoprotein in which the carbohydrate units are… Expand
National Institutes of Health

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Highly Cited
2009
Highly Cited
2009
Mechanical injury potentiates proteoglycan catabolism induced by interleukin-6 with soluble interleukin-6 receptor and tumor necrosis factor alpha in immature bovine and adult human articular…
OBJECTIVE Traumatic joint injury can damage cartilage and release inflammatory cytokines from adjacent joint tissue. The present… Expand
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Highly Cited
2006
Highly Cited
2006
Differential regulation of matrix degrading enzymes in a TNFalpha-induced model of nucleus pulposus tissue degeneration.
Intervertebral disc degeneration occurs commonly and is linked to persistent back pain and the development of disc herniation… Expand
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Highly Cited
2004
Highly Cited
2004
Effects of transforming growth factor-beta on aggrecanase production and proteoglycan degradation by human chondrocytes in vitro.
OBJECTIVE Aggrecan is degraded by Aggrecanases (ADAMTS-4 and -5) and MMPs, which cleave its core protein at different sites… Expand
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Highly Cited
2002
Highly Cited
2002
Cyclooxygenase 2-dependent prostaglandin E2 modulates cartilage proteoglycan degradation in human osteoarthritis explants.
OBJECTIVE To examine cyclooxygenase-2 (COX-2) enzyme expression, its regulation by interleukin-1 beta (IL-1 beta), and the role… Expand
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Highly Cited
1998
Highly Cited
1998
Cytokine-induced cartilage proteoglycan degradation is mediated by aggrecanase.
OBJECTIVE To evaluate the relationship between specific cleavage of aggrecan at the Glu373-Ala374 'aggrecanase' site and… Expand
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Highly Cited
1995
Highly Cited
1995
Monoclonal antibodies that specifically recognize neoepitope sequences generated by 'aggrecanase' and matrix metalloproteinase cleavage of aggrecan: application to catabolism in situ and in vitro.
Monoclonal antibodies have been prepared that react specifically with the neoepitopes present on proteoglycan degradation… Expand
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Highly Cited
1993
Highly Cited
1993
Inhibition of cartilage proteoglycan release by a specific inactivator of cathepsin B and an inhibitor of matrix metalloproteinases. Evidence for two converging pathways of chondrocyte-mediated…
OBJECTIVE To investigate mechanisms of cartilage matrix destruction by a study of the effects of a specific inactivator of… Expand
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Highly Cited
1993
Highly Cited
1993
Protection from interleukin 1 induced destruction of articular cartilage by transforming growth factor beta: studies in anatomically intact cartilage in vitro and in vivo.
The modulation of interleukin 1 (IL-1) effects on proteoglycan metabolism in intact murine patellar cartilage by transforming… Expand
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Highly Cited
1989
Highly Cited
1989
Independent effects of interleukin-1 on proteoglycan breakdown, proteoglycan synthesis, and prostaglandin E2 release from cartilage in organ culture.
Exposure of bovine nasal cartilage in culture to interleukin-1 (IL-1) leads to a time- and concentration-dependent stimulation of… Expand
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Highly Cited
1984
Highly Cited
1984
Pig catabolin is a form of interleukin 1. Cartilage and bone resorb, fibroblasts make prostaglandin and collagenase, and thymocyte proliferation is augmented in response to one protein.
Homogeneous catabolin from pig leucocytes induced proteoglycan breakdown, but not collagen breakdown, in explants of articular… Expand
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