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proteoglycan catabolic process
Known as:
proteoglycan breakdown
, proteoglycan catabolism
, proteoglycan degradation
The chemical reactions and pathways resulting in the breakdown of proteoglycans, any glycoprotein in which the carbohydrate units are…
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National Institutes of Health
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Highly Cited
2009
Highly Cited
2009
Mechanical injury potentiates proteoglycan catabolism induced by interleukin-6 with soluble interleukin-6 receptor and tumor necrosis factor alpha in immature bovine and adult human articular…
Y. Sui
,
Jennifer H. Lee
,
+8 authors
A. Grodzinsky
Arthritis & Rheumatism
2009
Corpus ID: 23328791
OBJECTIVE Traumatic joint injury can damage cartilage and release inflammatory cytokines from adjacent joint tissue. The present…
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Highly Cited
2008
Highly Cited
2008
Histone deacetylase inhibitors suppress interleukin-1beta-induced nitric oxide and prostaglandin E2 production in human chondrocytes.
N. Chabane
,
N. Zayed
,
+7 authors
H. Fahmi
Osteoarthritis and Cartilage
2008
Corpus ID: 206301377
Highly Cited
2006
Highly Cited
2006
Differential regulation of matrix degrading enzymes in a TNFalpha-induced model of nucleus pulposus tissue degeneration.
C. Séguin
,
M. Bojarski
,
R. Pilliar
,
P. Roughley
,
R. Kandel
Matrix Biology
2006
Corpus ID: 22996856
Highly Cited
2002
Highly Cited
2002
Cyclooxygenase 2-dependent prostaglandin E2 modulates cartilage proteoglycan degradation in human osteoarthritis explants.
M. Hardy
,
K. Seibert
,
+5 authors
C. Tripp
Arthritis & Rheumatism
2002
Corpus ID: 31395622
OBJECTIVE To examine cyclooxygenase-2 (COX-2) enzyme expression, its regulation by interleukin-1 beta (IL-1 beta), and the role…
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Review
2000
Review
2000
Mechanisms involved in cartilage proteoglycan catabolism.
B. Caterson
,
C. Flannery
,
C. Hughes
,
C. Little
Matrix Biology
2000
Corpus ID: 6978976
Highly Cited
1998
Highly Cited
1998
Cytokine-induced cartilage proteoglycan degradation is mediated by aggrecanase.
E. Arner
,
C. Hughes
,
C. Decicco
,
B. Caterson
,
M. Tortorella
Osteoarthritis and Cartilage
1998
Corpus ID: 19159384
OBJECTIVE To evaluate the relationship between specific cleavage of aggrecan at the Glu373-Ala374 'aggrecanase' site and…
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Highly Cited
1995
Highly Cited
1995
Monoclonal antibodies that specifically recognize neoepitope sequences generated by 'aggrecanase' and matrix metalloproteinase cleavage of aggrecan: application to catabolism in situ and in vitro.
C. Hughes
,
B. Caterson
,
A. Fosang
,
P. Roughley
,
J. Mort
Biochemical Journal
1995
Corpus ID: 25608500
Monoclonal antibodies have been prepared that react specifically with the neoepitopes present on proteoglycan degradation…
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Highly Cited
1993
Highly Cited
1993
Inhibition of cartilage proteoglycan release by a specific inactivator of cathepsin B and an inhibitor of matrix metalloproteinases. Evidence for two converging pathways of chondrocyte-mediated…
D. Buttle
,
C. Handley
,
M. Z. Ilic
,
J. Saklatvala
,
M. Murata
,
A. Barrett
Arthritis & Rheumatism
1993
Corpus ID: 26573122
OBJECTIVE To investigate mechanisms of cartilage matrix destruction by a study of the effects of a specific inactivator of…
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Highly Cited
1989
Highly Cited
1989
Independent effects of interleukin-1 on proteoglycan breakdown, proteoglycan synthesis, and prostaglandin E2 release from cartilage in organ culture.
E. Arner
,
M. Pratta
Arthritis & Rheumatism
1989
Corpus ID: 24860877
Exposure of bovine nasal cartilage in culture to interleukin-1 (IL-1) leads to a time- and concentration-dependent stimulation of…
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Highly Cited
1984
Highly Cited
1984
Pig catabolin is a form of interleukin 1. Cartilage and bone resorb, fibroblasts make prostaglandin and collagenase, and thymocyte proliferation is augmented in response to one protein.
J. Saklatvala
,
L. Pilsworth
,
S. Sarsfield
,
J. Gavrilovic
,
J. Heath
Biochemical Journal
1984
Corpus ID: 28479607
Homogeneous catabolin from pig leucocytes induced proteoglycan breakdown, but not collagen breakdown, in explants of articular…
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