proteoglycan catabolic process

Known as: proteoglycan breakdown, proteoglycan catabolism, proteoglycan degradation 
The chemical reactions and pathways resulting in the breakdown of proteoglycans, any glycoprotein in which the carbohydrate units are… (More)
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2009
2009
Mechanical injury potentiates proteoglycan catabolism induced by interleukin-6 with soluble interleukin-6 receptor and tumor necrosis factor alpha in immature bovine and adult human articular…
OBJECTIVE Traumatic joint injury can damage cartilage and release inflammatory cytokines from adjacent joint tissue. The present… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2007
2007
Estradiol induces heparanase-1 expression and heparan sulphate proteoglycan degradation in human endometrium.
BACKGROUND This study seeks to determine whether estrogen is able to regulate the expression of heparanase-1 (HPR1) in human… (More)
  • figure 1
  • table I
  • figure 2
  • table II
  • figure 3
Is this relevant?
2004
2004
Effects of transforming growth factor-beta on aggrecanase production and proteoglycan degradation by human chondrocytes in vitro.
OBJECTIVE Aggrecan is degraded by Aggrecanases (ADAMTS-4 and -5) and MMPs, which cleave its core protein at different sites… (More)
Is this relevant?
Highly Cited
2002
Highly Cited
2002
Cyclooxygenase 2-dependent prostaglandin E2 modulates cartilage proteoglycan degradation in human osteoarthritis explants.
OBJECTIVE To examine cyclooxygenase-2 (COX-2) enzyme expression, its regulation by interleukin-1 beta (IL-1 beta), and the role… (More)
Is this relevant?
2002
2002
Cyclosporin A inhibition of aggrecanase-mediated proteoglycan catabolism in articular cartilage.
OBJECTIVE To determine the effect of cyclosporin A (CSA) on aggrecanase- and matrix metalloproteinase (MMP)-mediated catabolism… (More)
Is this relevant?
2001
2001
Rhein, an active metabolite of diacerein, suppresses the interleukin-1alpha-induced proteoglycan degradation in cultured rabbit articular chondrocytes.
Diacerein has proved to be effective in the treatment of osteoarthritis. We investigated the effects of rhein, an active… (More)
  • table 1
  • table 2
  • table 3
Is this relevant?
1998
1998
Intra-articular levels of prostaglandin E2, hyaluronic acid, and chondroitin-4 and -6 sulfates in the temporomandibular joint synovial fluid of patients with internal derangement.
PURPOSE This study was conducted to measure the intra-articular levels of prostaglandin E2 (PGE2), hyaluronic acid, and… (More)
Is this relevant?
1993
1993
Protection from interleukin 1 induced destruction of articular cartilage by transforming growth factor beta: studies in anatomically intact cartilage in vitro and in vivo.
The modulation of interleukin 1 (IL-1) effects on proteoglycan metabolism in intact murine patellar cartilage by transforming… (More)
  • table 1
  • table 2
  • table 3
Is this relevant?
1992
1992
Inhibition of interleukin 1-mediated proteoglycan degradation in bovine articular cartilage explants by addition of sodium hyaluronate.
The effect of exogenous hyaluronate on normal cartilage metabolism and interleukin-1 (IL-1)-induced cartilage matrix degradation… (More)
Is this relevant?
1989
1989
Independent effects of interleukin-1 on proteoglycan breakdown, proteoglycan synthesis, and prostaglandin E2 release from cartilage in organ culture.
Exposure of bovine nasal cartilage in culture to interleukin-1 (IL-1) leads to a time- and concentration-dependent stimulation of… (More)
Is this relevant?