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proteoglycan biosynthetic process

Known as: proteoglycan synthesis, proteoglycan formation, proteoglycan anabolism 
The chemical reactions and pathways resulting in the formation of proteoglycans, any glycoprotein in which the carbohydrate units are… Expand
National Institutes of Health

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2 relations
negative regulation of proteoglycan biosynthetic processpositive regulation of proteoglycan biosynthetic process

Papers overview

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Highly Cited
1999
Highly Cited
1999
Notochordal cells interact with nucleus pulposus cells: regulation of proteoglycan synthesis.
The disappearance of notochordal cells is correlated with early degenerative changes in the intervertebral disc. With increased… Expand
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Highly Cited
1997
Highly Cited
1997
Evaluation of matrix scaffolds for tissue engineering of articular cartilage grafts.
Injury to articular cartilage predisposes that joint to further degeneration and eventually osteoarthritis. Recent studies have… Expand
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Highly Cited
1997
Highly Cited
1997
Effects of Hydrostatic Pressure on Matrix Synthesis and Matrix Metalloproteinase Production in the Human Lumbar Intervertebral Disc
Study Design. This study is a unique in vitro study on the effects of hydrostatic pressure on human intervertebral disc… Expand
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Review
1995
Review
1995
Insulin-like growth factors and their binding proteins: biological actions.
I. Introduction THE insulin-like growth factors were discovered on the basis of their ability to stimulate cartilage sulfation… Expand
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Highly Cited
1994
Highly Cited
1994
Nitric oxide mediates suppression of cartilage proteoglycan synthesis by interleukin-1.
Slices of rabbit articular cartilage synthesized large quantities of nitric oxide (NO) following exposure to human recombinant… Expand
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Highly Cited
1993
Highly Cited
1993
Direct transfer of transforming growth factor beta 1 gene into arteries stimulates fibrocellular hyperplasia.
The arterial wall responds to thrombosis or mechanical injury through the induction of specific gene products that increase… Expand
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Highly Cited
1992
Highly Cited
1992
Local stimulation of proteoglycan synthesis in articular cartilage explants by dynamic compression in vitro
Cultured bovine articular cartilage was subjected to 50 ms, 0.5–1.0 MPa compressions repeated at intervals of 2–60 s for 1.5 h… Expand
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Highly Cited
1990
Highly Cited
1990
Elevated expression of transforming growth factor-beta and proteoglycan production in experimental glomerulonephritis. Possible role in expansion of the mesangial extracellular matrix.
Glomerular accumulation of extracellular matrix is a prominent feature of progressive glomerulonephritis. Previously, we have… Expand
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Highly Cited
1986
Highly Cited
1986
Stimulation of proteoglycan biosynthesis by serum and insulin-like growth factor-I in cultured bovine articular cartilage.
The addition of foetal calf serum to explant cultures of adult bovine articular cartilage is known to stimulate proteoglycan… Expand
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Highly Cited
1982
Highly Cited
1982
Dedifferentiated chondrocytes reexpress the differentiated collagen phenotype when cultured in agarose gels
The differentiated phenotype of rabbit articular chondrocytes consists primarily of type II collagen and cartilage-specific… Expand
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