proteoglycan biosynthetic process

Known as: proteoglycan synthesis, proteoglycan formation, proteoglycan anabolism 
The chemical reactions and pathways resulting in the formation of proteoglycans, any glycoprotein in which the carbohydrate units are… (More)
National Institutes of Health

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negative regulation of proteoglycan biosynthetic processpositive regulation of proteoglycan biosynthetic process

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Highly Cited
1999
Highly Cited
1999
Proteoglycan synthesis by bovine keratocytes and corneal fibroblasts: maintenance of the keratocyte phenotype in culture.
PURPOSE To determine the effect of serum on morphology, growth, and proteoglycan synthesis by primary cultures of collagenase… (More)
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Highly Cited
1999
Highly Cited
1999
Notochordal cells interact with nucleus pulposus cells: regulation of proteoglycan synthesis.
The disappearance of notochordal cells is correlated with early degenerative changes in the intervertebral disc. With increased… (More)
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Highly Cited
1998
Highly Cited
1998
Mechanical compression alters proteoglycan deposition and matrix deformation around individual cells in cartilage explants.
We have used new techniques of cell-length scale quantitative autoradiography to assess matrix synthesis, deposition, and… (More)
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Highly Cited
1997
Highly Cited
1997
Evaluation of matrix scaffolds for tissue engineering of articular cartilage grafts.
Injury to articular cartilage predisposes that joint to further degeneration and eventually osteoarthritis. Recent studies have… (More)
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Highly Cited
1994
Highly Cited
1994
Nitric oxide mediates suppression of cartilage proteoglycan synthesis by interleukin-1.
Slices of rabbit articular cartilage synthesized large quantities of nitric oxide (NO) following exposure to human recombinant… (More)
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Highly Cited
1993
Highly Cited
1993
Direct transfer of transforming growth factor beta 1 gene into arteries stimulates fibrocellular hyperplasia.
The arterial wall responds to thrombosis or mechanical injury through the induction of specific gene products that increase… (More)
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Review
1993
Review
1993
Involvement of reactive oxygen species in kidney damage.
There is considerable evidence suggesting that reactive oxygen species (ROS) are implicated in the pathogenesis of ischemic… (More)
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Highly Cited
1990
Highly Cited
1990
Elevated expression of transforming growth factor-beta and proteoglycan production in experimental glomerulonephritis. Possible role in expansion of the mesangial extracellular matrix.
Glomerular accumulation of extracellular matrix is a prominent feature of progressive glomerulonephritis. Previously, we have… (More)
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Highly Cited
1988
Highly Cited
1988
Tumor formation dependent on proteoglycan biosynthesis.
The role proteoglycans play in tumor formation was examined by measuring the tumorigenicity of proteoglycan-deficient Chinese… (More)
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Highly Cited
1982
Highly Cited
1982
Dedifferentiated chondrocytes reexpress the differentiated collagen phenotype when cultured in agarose gels
The differentiated phenotype of rabbit articular chondrocytes consists primarily of type II collagen and cartilage-specific… (More)
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