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In plants, host response to pathogenic microbes is driven both by microbial perception and detection of modified-self. The… Expand ABSTRACT Few drugs targeting picornaviruses are available, making the discovery of antivirals a high priority. Here, we… Expand ABSTRACT Picornavirus RNA replication is initiated by VPg uridylylation, during which the hydroxyl group of the third tyrosine… Expand ABSTRACT Internally located, cis-acting RNA replication elements (cre) have been identified within the genomes of viruses… Expand The 5′ ends of all picornaviral RNAs are linked covalently to the genome-encoded peptide, VPg (or 3B). VPg linkage is thought to… Expand ABSTRACT Initiation of RNA synthesis by RNA-dependent RNA polymerases occurs when a phosphodiester bond is formed between the… Expand Picornaviruses have a peptide termed VPg covalently linked to the 5′-end of the genome. Attachment of VPg to the genome occurs in… Expand The VPg peptide, which is found in poliovirus infected cells either covalently bound to the 5′‐end of both plus and minus strand… Expand The virus genome-linked protein (VPg) coding region from rabbit hemorrhagic disease virus (RHDV) (isolate AST/89) was expressed… Expand ABSTRACT In addition to highly conserved stem-loop structures located in the 5′- and 3′-nontranslated regions, genome replication… Expand