protein tyrosine phosphatase, non-receptor type 1

Known as: Protein Tyrosine Phosphatase, Non Receptor Type 1, PTPase HA2, Protein Tyrosine Phosphatase 1B 
A subtype of non-receptor protein tyrosine phosphatases that includes two distinctive targeting motifs; an N-terminal motif specific for the INSULIN… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1988-2018
010203019882018

Papers overview

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2012
2012
Protein tyrosine phosphatase 1B (PTP1B), a key negative regulator of leptin and insulin signaling, is positively correlated with… (More)
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2011
2011
Inhibition of protein tyrosine phosphatase 1B (PTP1B) activity has been considered to be a promising therapy approach to treat… (More)
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Highly Cited
2008
Highly Cited
2008
Invasive cancer cells form dynamic adhesive structures associated with matrix degradation called invadopodia. Calpain 2 is a… (More)
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Highly Cited
2007
Highly Cited
2007
We investigated the role of protein tyrosine phosphatase 1B (PTP1B) in mammary tumorigenesis using both genetic and… (More)
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Highly Cited
2004
Highly Cited
2004
Obesity and type II diabetes are closely linked metabolic syndromes that afflict >100 million people worldwide. Although protein… (More)
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2003
2003
Protein tyrosine phosphatase 1B (PTP1B) is a negative regulator of insulin receptor (IR) signal transduction and a drug target… (More)
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2000
2000
We investigated the cellular mechanism(s) of insulin resistance associated with non-insulin dependent diabetes mellitus (NIDDM… (More)
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Highly Cited
1996
Highly Cited
1996
To understand the physiological role of protein-tyrosine phosphatase 1B (PTPase 1B) in insulin and insulin-like growth factor-I… (More)
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Highly Cited
1989
Highly Cited
1989
The amino acid sequence of the cytosolic human placenta protein-tyrosine-phosphatase 1B (PTPase 1B; protein-tyrosine-phosphate… (More)
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Highly Cited
1988
Highly Cited
1988
A major protein tyrosine phosphatase (PTPase 1B) has been isolated in essentially homogeneous form from the soluble and… (More)
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