protein geranylgeranyltransferase

Known as: ras protein GG transferase, Geranylgeranyl Transferase, GGTase I 
Alpha-beta heterodimeric human GGTase-I transfers a geranylgeranyl moiety to the Cys of a C-terminal CAAX motif in candidate proteins as a means of… (More)

Topic mentions per year

Topic mentions per year

1991-2017
0102019912017

Papers overview

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Highly Cited
2005
Highly Cited
2005
We refined the motifs for carboxy-terminal protein prenylation by analysis of known substrates for farnesyltransferase (FT… (More)
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2003
2003
Protein geranylgeranyltransferase type-I (GGTase-I), one of two CaaX prenyltransferases, is an essential enzyme in eukaryotes… (More)
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2003
2003
Agrin activates the transmembrane tyrosine kinase MuSK to mediate acetylcholine receptor (AChR) clustering at the neuromuscular… (More)
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Highly Cited
1999
Highly Cited
1999
Ras malignant transformation requires posttranslational modification by farnesyltransferase (FTase). Here we report on the design… (More)
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Highly Cited
1997
Highly Cited
1997
Recently we have shown that in fibroblasts (NIH 3T3 and Rat-1 cells) inhibition of protein geranylgeranylation leads to a G0/G1… (More)
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Highly Cited
1997
Highly Cited
1996
Highly Cited
1996
Cell-fate specification of the R7 photoreceptor cell is controlled by the sevenless receptor tyrosine kinase (SevRTK) and Ras1… (More)
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1992
1992
An enzyme capable of specifically modifying, with a geranylgeranyl isoprenoid, candidate proteins containing a consensus… (More)
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1991
1991
A protein geranylgeranyltransferase (PGT) that catalyzes the transfer of a 20-carbon prenyl group from geranylgeranyl… (More)
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Highly Cited
1991
Highly Cited
1991
Several proteins have been shown to be post-translationally modified on a specific C-terminal cysteine residue by either of two… (More)
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