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A “longevity” gene, sirtuin 1 (SIRT1), can attenuate age‐dependent induction of left ventricular dysfunction. This study aimed to… Expand Covalent attachment of small ubiquitin-like modifier (SUMO) to proteins is highly dynamic, and both SUMO–protein conjugation and… Expand Small ubiquitin-related modifiers (SUMOs) are ubiquitin-like polypeptides that become covalently conjugated to cellular proteins… Expand SUMOylation is a dynamic process, catalyzed by SUMO-specific ligases and reversed by Sentrin/SUMO-specific proteases (SENPs). The… Expand Defining the functional modules within transcriptional regulatory factors that govern switching between repression and activation… Expand Posttranslational modification with small ubiquitin-related modifier (SUMO) has emerged as a central regulatory mechanism of… Expand SUMO is a novel ubiquitin-like protein that can covalently modify a large number of nuclear proteins. SUMO modification has… Expand Ribosomal precursor particles are initially assembled in the nucleolus prior to their transfer to the nucleoplasm and export to… Expand ABSTRACT SUMO (also called Sentrin) is a ubiquitin-like protein that plays an important role in regulating protein function and… Expand Abstract Ligation of the ubiquitin-like protein SUMO (Smt3p) to other proteins is essential for viability of the yeast… Expand