protein-cysteine farnesyltransferase activity

Known as: FTase activity, farnesyl-diphosphate:protein-cysteine farnesyltransferase activity, protein farnesyltransferase activity 
Catalysis of the reaction: farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate. [EC:2.5.1.58, PMID:8621375]
National Institutes of Health

Topic mentions per year

Topic mentions per year

1981-2016
02419812016

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2006
2006
PURPOSE This pediatric phase I trial of tipifarnib determined the maximum-tolerated dose (MTD), pharmacokinetics, and… (More)
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2003
2003
PURPOSE R115777 is a selective nonpeptidomimetic inhibitor of farnesyltransferase (FTase), one of several enzymes responsible for… (More)
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2000
2000
Arabidopsis era1 was identified as an abscisic acid-hypersensitive mutant caused by disruptions or deletions of the gene for the… (More)
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Highly Cited
1999
Highly Cited
1999
Cell walls are crucial for development, signal transduction, and disease resistance in plants. Cell walls are made of cellulose… (More)
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1999
1999
Protein farnesyltransferase (FTase) is a key enzyme responsible for the lipid modification of a large and important number of… (More)
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1997
1997
Farnesylation of p21Ras by farnesyltransferase (FTase) is obligatory for anchoring p21Ras to the plasma membrane, where it can be… (More)
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1996
1996
Protein farnesyltransferase (FTase) is a zinc metalloenzyme that performs a post-translational modification on many proteins that… (More)
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Highly Cited
1991
Highly Cited
1991
Several proteins have been shown to be post-translationally modified on a specific C-terminal cysteine residue by either of two… (More)
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1991
1991
In the yeast Saccharomyces cerevisiae, mutations in either of two unlinked genes, RAM1 or RAM2, abolish the farnesyltransferase… (More)
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1991
1991
Protein prenylation occurs by modification of proteins with one of at least two isoprenoids, the farnesyl group and the… (More)
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