proteasome-mediated ubiquitin-dependent protein catabolic process

Known as: proteasomal ubiquitin-dependent protein degradation, proteasomal ubiquitin-dependent protein catabolism, proteasomal ubiquitin-dependent protein breakdown 
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent… (More)
National Institutes of Health

Papers overview

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2009
2009
Prolyl-4-hydroxylase domain (PHD) proteins are 2-oxoglutarate and dioxygen-dependent enzymes that mediate the rapid destruction… (More)
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2008
2008
PURPOSE Pancreatic ductal adenocarcinoma (PDAC) progresses rapidly and exhibits profound resistance to treatment. We recently… (More)
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2008
2008
Although the covalent attachment of a polyubiquitin is the prevailing paradigm for entry into proteasomes, accumulating evidence… (More)
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2007
2007
Efficient induction of apoptosis requires not only the activation of death-promoting proteins but also the inactivation of… (More)
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Highly Cited
2006
Highly Cited
2006
The neuronal ubiquitin/proteasomal pathway has been implicated in the pathogenesis of Alzheimer's disease (AD). We now show that… (More)
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Highly Cited
2006
Highly Cited
2006
Mutations in genes encoding both DJ-1 and pten-induced kinase 1 (PINK1) are independently linked to autosomal recessive early… (More)
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Highly Cited
2005
Highly Cited
2005
5-Azacytidine- and 5-aza-deoxycytidine (5-aza-CdR)-mediated reactivation of tumor suppressor genes silenced by promoter… (More)
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Highly Cited
2005
Highly Cited
2005
Inherited prion diseases are linked to mutations in the prion protein (PrP) gene, which favor conversion of PrP into a… (More)
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Review
2005
Review
2005
The ubiquitin-proteasomal pathway of degradation of proteins is activated or repressed in response to a number of environmental… (More)
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Review
2001
Review
2001
A unifying feature of neurodegenerative diseases is the abnormal accumulation and processing of mutant or damaged intra- and… (More)
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