Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

proteasome-mediated ubiquitin-dependent protein catabolic process

Known as: proteasomal ubiquitin-dependent protein degradation, proteasomal ubiquitin-dependent protein catabolism, proteasomal ubiquitin-dependent protein breakdown 
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Prolyl-4-hydroxylase domain (PHD) proteins are 2-oxoglutarate and dioxygen-dependent enzymes that mediate the rapid destruction… Expand
Is this relevant?
Highly Cited
2008
Highly Cited
2008
Purpose: Pancreatic ductal adenocarcinoma (PDAC) progresses rapidly and exhibits profound resistance to treatment. We recently… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2008
Highly Cited
2008
Although the covalent attachment of a polyubiquitin is the prevailing paradigm for entry into proteasomes, accumulating evidence… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2006
Highly Cited
2006
The neuronal ubiquitin/proteasomal pathway has been implicated in the pathogenesis of Alzheimer's disease (AD). We now show that… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2006
Highly Cited
2006
Mutations in genes encoding both DJ-1 and pten-induced kinase 1 (PINK1) are independently linked to autosomal recessive early… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2005
Highly Cited
2005
ABSTRACT 5-Azacytidine- and 5-aza-deoxycytidine (5-aza-CdR)-mediated reactivation of tumor suppressor genes silenced by promoter… Expand
Is this relevant?
Highly Cited
2005
Highly Cited
2005
Inherited prion diseases are linked to mutations in the prion protein (PrP) gene, which favor conversion of PrP into a… Expand
Is this relevant?
Highly Cited
2004
Highly Cited
2004
CASK acts as a coactivator for Tbr-1, an essential transcription factor in cerebral cortex development. Presently, the molecular… Expand
  • figure 1
  • figure 3
  • figure 5
  • figure 6
  • figure 7
Is this relevant?
Review
2001
Review
2001
A unifying feature of neurodegenerative diseases is the abnormal accumulation and processing of mutant or damaged intra- and… Expand
Is this relevant?
Highly Cited
2001
Highly Cited
2001
0166-2236/01/$ – see front matter ©2001 Elsevier Science Ltd. All rights reserved. PII: S0166-2236(00)01998-6 Most, if not all… Expand
Is this relevant?