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propylisopropylacetamide

Known as: 2-isopropylvaleramide 
 
National Institutes of Health

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2 relations

Broader (1)

Allylisopropylacetamide
analogs & derivatives

Papers overview

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2013
2013
Propylisopropylacetic acid (PIA), a constitutional isomer of valproic acid, uncompetitively inhibits arachidonic acid acylation by rat acyl-CoA synthetase 4: a potential drug for bipolar disorder.
BACKGROUND Mood stabilizers used for treating bipolar disorder (BD) selectively downregulate arachidonic acid (AA) turnover… Expand
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2008
2008
Evaluation of the enantioselective antiallodynic and pharmacokinetic profile of propylisopropylacetamide, a chiral isomer of valproic acid amide
Propylisopropylacetamide (PID) is a chiral CNS-active constitutional isomer of valpromide, the amide derivative of the major… Expand
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2007
2007
Potent anticonvulsant urea derivatives of constitutional isomers of valproic acid.
Valproic acid (VPA) is a major antiepileptic drug (AED); however, its use is limited by two life-threatening side effects… Expand
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1989
1989
Structure–Pharmacokinetic Relationships in a Series of Valpromide Derivatives with Antiepileptic Activity
The following valpromide (VPD) derivatives were synthesized and their structure–pharmacokinetic relationships explored… Expand
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1986
1986
Uroporphyrin accumulation produced by halogenated biphenyls in chick-embryo hepatocytes. Reversal of the accumulation by piperonyl butoxide.
Cultures of chick-embryo hepatocytes were used to study the mechanism by which 3,4,3',4'-tetrachlorobiphenyl and 2,4,5,3',4… Expand
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1984
1984
Inhibition of uroporphyrinogen decarboxylase by halogenated biphenyls in chick hepatocyte cultures. Essential role for induction of cytochrome P-448.
Uroporphyrinogen decarboxylase (EC 4.1.1.37) activity was assayed in cultures of chick-embryo hepatocytes by the changes in… Expand
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1983
1983
The carcinogen chromate causes DNA damage and inhibits drug-mediated induction of porphyrin accumulation and glucuronidation in chick embryo hepatocytes.
DNA damage by chromate in chick embryo hepatocytes has been correlated with the effect of chromate on inducible cell functions… Expand
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1982
1982
Increases in cytochrome p-450 in cultured hepatocytes mediated by 3- and 4-carbon alcohols.
The amount of cytochrome P-450 was increased to different extents after treatment of cultured chick embryo hepatocytes with n… Expand
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1979
1979
Hormonal requirements for the induction of cytochrome P-450 in hepatocytes cultured in a serum-free medium.
Abstract Drug mediated induction of cytochrome P450 was studied in cultures of hepatocytes that had never been cultured in the… Expand
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1974
1974
Drug-induced porphyrin biosynthesis--XII. Levels of cytochrome P-450 in chick embryo liver following administration of allylisopropylacetamide and propylisopropylacetamide.
Allylisopropylacetamide caused a decrease in the level of chick embryo liver cytochrome P-450 1 h after administration, followed… Expand
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