propargylamine

The synthesis, biochemical evaluation, ADMET, toxicity and molecular modeling of novel multi-target-directed Donepezil… Expand

Histone methylation regulates diverse chromatin-templated processes, including transcription. The recent discovery of the first… Expand

Histone demethylase LSD1 is a flavin-dependent amine oxidase that catalyzes the oxidative removal of one or two methyl groups… Expand

The anti-Parkinson drug, rasagiline (N-propargyl-(1R)-aminoindan) promotes neuronal survival, via neuroprotective activity… Expand

Rasagiline is a novel second-generation propargylamine that irreversibly and selectively inhibits monoamine oxidase type B (MAO-B… Expand

The mitochondria are directly involved in cell survival and death. Drugs that protect mitochondria viability and prevent… Expand

Rasagiline (N-propargyl-1-(R)-aminoindan) is a selective, irreversible monoamine oxidase B (MAO B) inhibitor which has been… Expand

This study provides new insights into neuroprotection involving interaction of protein kinase C (PKC) pathway with Bcl-2 family… Expand

(-)-Deprenyl and structurally related propargylamines increase neuronal survival independently of monoamine oxidase B (MAO-B… Expand

A potent inhibitor of type B monoamine oxidase, (-)deprenyl, is known to protect or rescue dying neurons, independent of… Expand