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procollagen-lysine 5-dioxygenase activity

Known as: protocollagen lysine hydroxylase activity, protocollagen lysine dioxygenase activity, procollagen-L-lysine,2-oxoglutarate:oxygen oxidoreductase (5-hydroxylating) 
Catalysis of the reaction: procollagen L-lysine + 2-oxoglutarate + O2 = procollagen 5-hydroxy-L-lysine + succinate + CO2. [EC:1.14.11.4]
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
Lysyl hydroxylase 3 (LH3, encoded by PLOD3) is a multifunctional enzyme capable of catalyzing hydroxylation of lysyl residues and… Expand
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Highly Cited
2002
Highly Cited
2002
Lysyl hydroxylase (LH) catalyzes the formation of hydroxylysine in collagens; three human isoenzymes have been cloned so far. We… Expand
1995
1995
A cDNA library from rat lung was screened with a chicken lysyl hydroxylase cDNA, and several overlapping rat lysyl hydroxylase… Expand
Highly Cited
1987
Highly Cited
1987
The effect of minoxidil on lysyl hydroxylase activity and proliferation of human skin fibroblasts in culture was examined… Expand
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1981
1981
Abstract Studies with confluent human skin fibroblasts maintained in 0.5% serum supplemented medium have given new insight into… Expand
1981
1981
6-N-(3-/sup 3/H)Trimethyl-DL-lysine was synthesized from 6-N-acetyl-L-lysine by the following chemical scheme: 6-N-acetyl-L… Expand
1976
1976
  • L. Ryhänen
  • Biochimica et biophysica acta
  • 1976
  • Corpus ID: 6316837
A purification of up to 4000-fold is reported for lysyl hydroxylase (EC 1.14.11.4) from extract of chick-embryo homogenate and… Expand
1974
1974
Abstract Developmental changes in protocollagen lysyl hydroxylase activity were studied in whole chick embryos and in several… Expand
Highly Cited
1974
Highly Cited
1974
1. Subcellular fractions of freshly isolated matrix-free embryonic chick tendon and sternal cartilage cells have been… Expand
1973
1973
Abstract A method is described for the assay of protocollagen lysyl hydroxylase activity in human skin specimens of 100 to 300 mg… Expand