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pro-islet amyloid polypeptide

Known as: proIAPP 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

Amyloid

Papers overview

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2017
2017
Loss of prohormone convertase 2 promotes beta cell dysfunction in a rodent transplant model expressing human pro-islet amyloid polypeptide
Aims/hypothesisA contributor to beta cell failure in type 2 diabetes and islet transplants is amyloid formation by aggregation of… 
2016
2016
Modeling of beta-cell Metabolic Activity and Islet Function : a Systems Approach to Type II Diabetes
Diabetes has gained growing attendance as one of the key non communicable diseases (NCD) with the World Health Organization… 
2015
2015
Islet amyloid polypeptide (IAPP) in Type 2 diabetes and Alzheimer disease
The misfolding and aggregation of the beta cell hormone islet amyloid polypeptide (IAPP) into amyloid fibrils is the main… 
Highly Cited
2009
Highly Cited
2009
Amyloidogenic propensities and conformational properties of ProIAPP and IAPP in the presence of lipid bilayer membranes.
2008
2008
There is a role for proIAPP in islet amyloid fibrillogenesis
Amyloid is defined as extracellular protein aggregates with a characteristic fibrillar ultra-structure, Congo red affinity and a… 
2007
2007
Pancreatic Islet Amyloid and Diabetes
Deposition of amyloid in pancreatic islets is a feature of type 2 diabetes in man but the causal factors are unknown. Progressive… 
2006
2006
Characterization of the heparin binding site in the N-terminus of human pro-islet amyloid polypeptide: implications for amyloid formation.
Islet amyloid deposits are a characteristic pathological hallmark of type 2 diabetes mellitus. Islet amyloid polypeptide (IAPP… 
2006
2006
Proislet Amyloid Polypeptide (proIAPP) : Impaired Processing is an Important Factor in Early Amyloidogenesis in Type 2 Diabetes
Amyloid formation is cytotoxic and can activate the caspase cascade. Here, we monitor caspase-3-like activity as reduction of… 
1992
1992
Effects of islet amyloid polypeptide (IAPP) on insulin biosynthesis or secretion in rat islets and mouse βTC3 cells. Biosynthesis of IAPP in mouse βTC3 cells
1992
1992
Effects of islet amyloid polypeptide (IAPP) on insulin biosynthesis or secretion in rat islets and mouse beta TC3 cells. Biosynthesis of IAPP in mouse beta TC3 cells.
Effects of rat islet amyloid polypeptide (IAPP) on insulin biosynthesis and secretion were examined in isolated rat islets and… 
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