primitive erythrocyte differentiation
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Reconstruction of the molecular pathways controlling organ development has been hampered by a lack of methods to resolve… Expand We elucidate the cellular and molecular kinetics of the stepwise differentiation of human embryonic stem cells (hESCs) to… Expand The enucleated definitive erythrocytes of mammals are unique in the animal kingdom. The observation that yolk sac-derived… Expand c-Myc promotes cell growth and transformation by ill-defined mechanisms. c-myc(-/-) mice die by embryonic day 10.5 (E10.5) with… Expand In this study, we have mapped the onset of hematopoietic development in the mouse embryo using colony-forming progenitor assays… Expand Cbfa2 (AML1) encodes the DNA-binding subunit of a transcription factor in the small family of core-binding factors (CBFs). Cbfa2… Expand In vertebrates, hematopoietic and vascular progenitors develop from ventral mesoderm. The first primitive wave of hematopoiesis… Expand The generation of blood cells, haematopoiesis, in the mouse embryo begins with the development of primitive nucleated erythroid… Expand Core binding factor beta (CBF beta) is considered to be a transcriptional coactivator that dimerizes with transcription factors… Expand Erythropoietin (EPO) is the principal growth factor regulating the production of circulating erythrocytes. We introduced null… Expand