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prethrombin 2

National Institutes of Health

Papers overview

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2008
2008
Fate of Membrane-bound Reactants and Products during the Activation of Human Prothrombin by Prothrombinase*
Membrane binding by prothrombin, mediated by its N-terminal fragment 1 (F1) domain, plays an essential role in its proteolytic… 
2007
2007
Expression of Allosteric Linkage between the Sodium Ion Binding Site and Exosite I of Thrombin during Prothrombin Activation*
The specificity of thrombin for procoagulant and anticoagulant substrates is regulated allosterically by Na+. Ordered cleavage of… 
2003
2003
Effects of Activation Peptide Bond Cleavage and Fragment 2 Interactions on the Pathway of Exosite I Expression during Activation of Human Prethrombin 1 to Thrombin*
Activation of prothrombin (Pro) by factor Xa to form thrombin occurs by proteolysis of Arg271-Thr272 and Arg320-Ile321, resulting… 
2002
2002
Role of procoagulant lipids in human prothrombin activation. 2. Soluble phosphatidylserine upregulates and directs factor X(a) to appropriate peptide bonds in prothrombin.
Activation of human prothrombin to thrombin (II(a)) by factor X(a) during blood coagulation requires proteolysis of two bonds and… 
2001
2001
Activation of Human Prothrombin by Human Prothrombinase
The kinetics of the activation of human prothrombin catalyzed by human prothrombinase was studied using the fluorescent a… 
1993
1993
Hydrophobic affinity chromatography of human thrombin.
Hydrophobic affinity chromatography on p-chlorobenzylamido-agarose (p-CBA-agarose) was used to characterize various modified… 
1987
1987
Development of a radioimmunoassay for quantitating prethrombin 2 in human plasma.
We have developed a radioimmunoassay (RIA) for prethrombin 2 (Pr2), a potential intermediate in the transformation of prothrombin… 
Highly Cited
1987
Highly Cited
1987
Activation of human prothrombin by human prothrombinase. Influence of factor Va on the reaction mechanism.
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