pregnane X receptor

Known as: nuclear receptor subfamily 1, group I, member 2, steroid and xenobiotic receptor (SXR), steroid X receptor 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1998-2018
05101519982018

Papers overview

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2013
2013
We conducted a randomized, open, placebo-controlled crossover trial to investigate the effects of the pregnane X receptor (PXR… (More)
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2011
2011
Phthalates and other endocrine-disruptive chemicals are manufactured in large quantities for use as plasticizers and other… (More)
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2009
2009
The steroid and xenobiotic-responsive human pregnane X receptor (PXR) binds a broad range of structurally diverse compounds. The… (More)
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2009
2009
Acetaminophen (APAP) is safe at therapeutic levels but causes hepatotoxicity via N-acetyl-p-benzoquinone imine-induced oxidative… (More)
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Highly Cited
2006
Highly Cited
2006
While it has long been known that inflammation and infection reduce expression of hepatic cytochrome P450 (CYP) genes involved in… (More)
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2003
2003
Although the glucocorticoid receptor (GR) facilitates the xenobiotic-induced expression of CYP2B in rodents, its role in the… (More)
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Highly Cited
2002
Highly Cited
2002
The fully active dihydroxylated metabolite of vitamin D(3) induces the expression of CYP3A4 and, to a lesser extent, CYP2B6 and… (More)
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2002
2002
The rat organic anion transporting polypeptide 2 (oatp2; Slc21a5) is a liver transporter that mediates the uptake of a variety of… (More)
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Highly Cited
2001
Highly Cited
2001
The pregnane X receptor (PXR) is the molecular target for catatoxic steroids such as pregnenolone 16alpha-carbonitrile (PCN… (More)
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Highly Cited
1998
Highly Cited
1998
The cytochrome P-450 monooxygenase 3A4 (CYP3A4) is responsible for the oxidative metabolism of a wide variety of xenobiotics… (More)
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