pre-T cell receptor complex
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Le blocage du processus de maturation est un element central de l’oncogenese des LAL-Tcomme en temoigne la forte correlation… Expand ABSTRACT The human pre-T-cell receptor alpha (TCRα; pTα) gene encodes a polypeptide which associates with the TCRβ chain and CD3… Expand En route to maturing as T cell receptor (TCR) αβ-expressing cells, the development of thymocytes is contingent on expression of a… Expand Functional rearrangement at the TCRbeta locus leads to surface expression on developing pre-T cells of a pre-TCR complex composed… Expand Thymocyte development is characterized by the stage-specific expression of CD4 and CD8 surface molecules (1). The earliest thymic… Expand We have reported that a 12-kDa molecule (pTAC12 as a pre-T cell receptor (TCR)-associated chain) was associated as a dimer with… Expand The pre‐T‐cell receptor (TCR) complex, which consists of a heterodimer of the TCRβ‐chain and the pre‐TCRα‐chain, is known to… Expand The pre-T cell receptor (TCR) complex regulates early T cell development and consists of a heterodimer of the TCR-beta subunit in… Expand The pre-T cell receptor (TCR) complex regulates early T cell development and consists of a heterodimer of the TCR-13 subunit in… Expand The T cell antigen receptor (TCR) beta chain regulates early T cell development in the absence of the TCR alpha chain. The… Expand