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pre-T cell receptor complex

Known as: pre-T cell receptor complex location, pre-T-cell receptor complex, pre-TCR complex 
A receptor complex found on immature T cells consisting of a T cell receptor beta chain and the pre-TCR-alpha chain, along with additional signaling… 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

integral component of plasma membrane

Papers overview

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2010
2010
Blocage de maturation thymique et aberration des recombinaisons V(D)J : modèle des Leucémies Aigües Lymphoblastiques de la lignée T exprimant les onco-protéines à homéodomaines TLX1 et TLX3
Le blocage du processus de maturation est un element central de l’oncogenese des LAL-Tcomme en temoigne la forte correlation… 
2006
2006
Human T-Cell Leukemia Virus Type 1 Tax Protein Down-Regulates Pre-T-Cell Receptor Alpha Gene Transcription in Human Immature Thymocytes
ABSTRACT The human pre-T-cell receptor alpha (TCRα; pTα) gene encodes a polypeptide which associates with the TCRβ chain and CD3… 
2002
2002
Molecular Mechanisms of Pre-T Cell Receptor-induced Survival*
En route to maturing as T cell receptor (TCR) αβ-expressing cells, the development of thymocytes is contingent on expression of a… 
2001
2001
Differential developmental regulation and functional effects on pre-TCR surface expression of human pTalpha(a) and pTalpha(b) spliced isoforms.
Functional rearrangement at the TCRbeta locus leads to surface expression on developing pre-T cells of a pre-TCR complex composed… 
2000
2000
Transfection and transcription of genes in developing thymocytes.
Thymocyte development is characterized by the stage-specific expression of CD4 and CD8 surface molecules (1). The earliest thymic… 
1998
1998
Regulation of Vbeta germline transcription in RAG-deficient mice by the CD3epsilon-mediated signals: implication of Vbeta transcriptional regulation in TCR beta allelic exclusion.
During the thymic development of alphabeta lineage T cells, maturation of the CD4- CD8- double-negative (DN) cells into the CD4… 
1998
1998
A limited role for beta-selection during gamma delta T cell development.
T cells belong to two distinct lineages expressing either alpha beta or gamma delta TCR. During alpha beta T cell development, it… 
1997
1997
Subunit composition of the pre‐T‐cell receptor complex analysed by monoclonal antibody against the pre‐T‐cell receptor α chain
The pre‐T‐cell receptor (TCR) complex, which consists of a heterodimer of the TCRβ‐chain and the pre‐TCRα‐chain, is known to… 
Highly Cited
1997
Highly Cited
1997
Subunit Composition of Pre–T Cell Receptor Complexes Expressed by Primary Thymocytes: CD3δ Is Physically Associated but Not Functionally Required
Maturation of immature CD4−CD8− (DN) thymocytes to the CD4+CD8+ (DP) stage of development is driven by signals transduced through… 
1995
1995
The PreT Cell Receptor ( TCR ) Complex is Functionally Coupled to the TCR-~ Subunit
The pre-T cell receptor (TCR) complex regulates early T cell development and consists of a heterodimer of the TCR-13 subunit in… 
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