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pradigastat

 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

AcetatesAminopyridines

Narrower (1)

LCQ908

Papers overview

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2017
2017
Pradigastat disposition in humans: in vivo and in vitro investigations
Abstract 1. Pradigastat is a potent and specific diacylglycerol acyltransferase-1 (DGAT1) inhibitor effective in lowering… Expand
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2016
2016
Assessment of pharmacokinetic drug-drug interaction between pradigastat and atazanavir or probenecid.
Pradigastat, a novel diacylglycerol acyltransferase-1 inhibitor, has activity in common metabolic diseases associated with… Expand
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2016
2016
The DGAT1 inhibitor pradigastat does not induce photosensitivity in healthy human subjects: a randomized controlled trial using three defined sunlight exposure conditions.
The DGAT1 inhibitor, pradigastat, demonstrated a mild phototoxicity signal in preclinical studies. Therefore, this clinical trial… Expand
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2016
2016
Effect of Pradigastat, a Diacylglycerol Acyltransferase 1 Inhibitor, on the QTcF Interval in Humans
Pradigastat, a novel diacylglycerol acyltransferase 1 inhibitor, has been studied in familial chylomicronemia syndrome. To… Expand
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Highly Cited
2015
Highly Cited
2015
Effect of the DGAT1 inhibitor pradigastat on triglyceride and apoB48 levels in patients with familial chylomicronemia syndrome
BackgroundFamilial chylomicronemia syndrome (FCS) is a rare lipid disease caused by complete lipoprotein lipase (LPL) deficiency… Expand
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2015
2015
Pharmacokinetics, pharmacodynamics, safety, and tolerability of pradigastat, a novel diacylglycerol acyltransferase 1 inhibitor in overweight or obese, but otherwise healthy human subjects.
Pradigastat is a potent and selective inhibitor of diacylglycerol acyltransferase 1, an enzyme highly expressed in the small… Expand
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2015
2015
Evaluation of a potential transporter-mediated drug interaction between rosuvastatin and pradigastat, a novel DGAT-1 inhibitor.
OBJECTIVE An in vitro drugdrug interaction (DDI) study was performed to assess the potential for pradigastat to inhibit breast… Expand
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2015
2015
Effect of Hepatic Impairment on the Pharmacokinetics of Pradigastat, a Diacylglycerol Acyltransferase 1 (DGAT1) Inhibitor
Background and ObjectivePradigastat, a novel diacylglycerol acyltransferase 1 inhibitor, is under development to treat familial… Expand
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2014
2014
Pharmacokinetic and pharmacodynamic drug-drug interaction assessment between pradigastat and digoxin or warfarin.
Pradigastat, a novel diacylglycerol acyltransferase-1 inhibitor, was evaluated for both pharmacokinetic (PK) and pharmacodynamic… Expand
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2013
2013
The DGAT1 inhibitor Pradigastat Decreases Chylomicron Secretion and Prevents Postprandial Triglyceride Elevation in Humans
 
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