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polynucleotide 5'-hydroxyl-kinase activity

Known as: polynucleotide 5'-hydroxyl kinase (phosphorylating) activity, 5'-hydroxyl polynucleotide kinase activity, polynucleotide 5'-hydroxy-kinase activity 
Catalysis of the reaction: NTP + 5'-dephosphopolynucleotide = NDP + 5'-phosphopolynucleotide. The polynucleotide may be DNA or RNA. [EC:2.7.1.78]
National Institutes of Health

Papers overview

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2017
2017
5'-Polynucleotide kinase such as T4 polynucleotide kinase (T4 PNK) may catalyze the phosphorylation of 5'-hydroxyl termini in… Expand
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2015
2015
A highly sensitive electrochemiluminescence (ECL) strategy was developed for the protein kinase A (PKA) activity and inhibition… Expand
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Highly Cited
2014
Highly Cited
2014
A label-free, oligonucleotide-based, switch-on luminescence detection method for T4 polynucleotide kinase activity has been… Expand
Highly Cited
2012
Highly Cited
2012
Piwi-interacting (pi) RNAs are germline-expressed small RNAs linked to epigenetic programming. C. elegans piRNAs are thought to… Expand
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Highly Cited
2009
Highly Cited
2009
ABSTRACT Oxidative stress is a major source of chromosome single-strand breaks (SSBs), and the repair of these lesions is… Expand
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Highly Cited
2009
Highly Cited
2009
Short-patch repair of DNA single-strand breaks and gaps (SSB) is coordinated by XRCC1, a scaffold protein that recruits the DNA… Expand
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Highly Cited
2009
Highly Cited
2009
The DNA-binding inorganic compound cisplatin is one of the most successful anticancer drugs. The detailed mechanism by which… Expand
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Highly Cited
2005
Highly Cited
2005
Phosphorylation of nucleic acids is an indispensable process to repair strand interruption of nucleic acids. We have studied the… Expand
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Highly Cited
2001
Highly Cited
2001
XRCC1 protein is required for DNA single-strand break repair and genetic stability but its biochemical role is unknown. Here, we… Expand
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1986
1986
An RNA ligase that catalyzes the formation of a 2'-phosphomonoester-3',5'-phosphodiester bond in the presence of ATP and Mg2+ was… Expand