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polyethylene glycol-recombinant human megakaryocyte growth and development factor

Known as: PEG-rHuMGDF, Polyethylene Glycosylated Recombinant Human MGDF, PEG Recombinant Human Megakaryocyte Growth and Development Factor 
A pegylated formulation containing a recombinant growth factor with thrombopoietic activity. The recombinant human megakaryocyte growth and… 
National Institutes of Health

Related topics

Related topics

4 relations

Narrower (1)

Megagen

Broader (3)

Polyethylene GlycolsRecombinant ProteinsThrombopoietin

Papers overview

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Highly Cited
2013
Highly Cited
2013
Inhibition of Megakaryocyte Development in the Bone Marrow Underlies Dengue Virus-Induced Thrombocytopenia in Humanized Mice
ABSTRACT A characteristic clinical feature of dengue virus infection is thrombocytopenia, though its underlying mechanism is not… 
Highly Cited
2001
Highly Cited
2001
Phosphatidylinositol 3-Kinase Is Necessary but Not Sufficient for Thrombopoietin-induced Proliferation in Engineered Mpl-bearing Cell Lines as Well as in Primary Megakaryocytic Progenitors*
Thrombopoietin and its receptor (Mpl) support survival and proliferation in megakaryocyte progenitors and in BaF3 cells… 
Highly Cited
2000
Highly Cited
2000
Thrombin Inhibits Tumor Cell Growth in Association with Up-regulation of p21 waf/cip1 and Caspases via a p53-independent, STAT-1-dependent Pathway*
Thrombin, a multifunctional protein, has been found to be involved in cellular mitogenesis, tumor growth, and metastasis, in… 
Highly Cited
1998
Highly Cited
1998
Multilineage hematopoietic recovery by a single injection of pegylated recombinant human megakaryocyte growth and development factor in myelosuppressed mice.
Previous studies have shown that daily multiple administration of pegylated recombinant human megakaryocyte growth and… 
Review
1997
Review
1997
Stimulation of Megakaryocyte and Platelet Production by a Single Dose of Recombinant Human Thrombopoietin in Patients with Cancer
Thrombocytopenia is an important clinical problem in the management of patients in hematology and oncology practices. In the… 
Highly Cited
1996
Highly Cited
1996
Thrombopoietic effects of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) in patients with advanced cancer
Highly Cited
1996
Highly Cited
1996
Regulation of platelet production and function by megakaryocyte growth and development factor in nonhuman primates.
The primary physiologic regulator of platelet production, Mpl ligand, has recently been cloned and characterized. To define the… 
Highly Cited
1996
Highly Cited
1996
Administration of pegylated recombinant human megakaryocyte growth and development factor to humans stimulates the production of functional platelets that show no evidence of in vivo activation.
This report describes the effect of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) on… 
1996
1996
Glycosaminoglycans enhance megakaryocytopoiesis by modifying the activities of hematopoietic growth regulators
We have previously reported that heparin is capable of stimulating in vitro and in vivo megakaryocytopoiesis in mice and has a… 
Highly Cited
1993
Highly Cited
1993
Recombinant human interleukin-11 stimulates megakaryocytopoiesis and increases peripheral platelets in normal and splenectomized mice.
The effects of recombinant human interleukin-11 (rhIL-11) on in vivo mouse megakaryocytopoeisis were examined. Normal C57Bl/6… 
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