poly(maleic acid-styrene)neocarzinostatin

Abstract History of the EPR (enhanced permeability and retention) effect is discussed, which goes back to the analyses of… Expand

The purpose of this study is to evaluate the improved method of arterial infusion therapy of SMANCS (SX) with lipiodol under the… Expand

Both enhanced vascular permeability and angiogenesis of tumor sustain rapid growth of tumor involving many vascular mediators and… Expand

The biodistribution of soluble macromolecules is governed extensively by their ability to penetrate endothelial layers. Many… Expand

The advantages and disadvantages of macromolecular drugs, particularly on synthetic polymer-protein conjugates, are described in… Expand

We previously found that a polymer conjugated to the anticancer protein neocarzinostatin, named smancs, accumulated more in tumor… Expand

An anticancer agent of intermediate molecular weight and having both a hydrophilic and hydrophobic nature was developed by… Expand

Twenty-four patients with various solid tumors including metastatic liver cancer and cancer of the lung, gallbladder, and… Expand

Highly malignant rabbit tumor (VX-2) was implanted at the periphery of the liver in 63 rabbits. Selective delivery of the… Expand

A clinical evaluation of arterial infusion of high-molecular-weight antitumor agent SMANCS dissolved in lipid lymphographic agent… Expand