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platencin

 
National Institutes of Health

Papers overview

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2013
2013
The synthesis of the complex tricyclic core of the terpenoid antibiotic platencin is achieved in a concise, protecting group-free… Expand
Highly Cited
2011
Highly Cited
2011
Platensimycin (PTM) and platencin (PTN) are potent and selective inhibitors of bacterial and mammalian fatty acid synthases and… Expand
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2011
2011
Platensimycin (1a) and platencin (2) are inhibitors of FabF and FabF/H bacterial fatty acid synthase. The discovery of natural… Expand
2010
2010
A formal total synthesis of platencin from a simple aromatic precursor is described. Transformation of the aromatic compound into… Expand
Highly Cited
2009
Highly Cited
2009
ABSTRACT Platensimycin, which is isolated from Streptomyces platensis MA7327, and platencin, which is isolated from S. platensis… Expand
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2009
2009
An asymmetric Diels-Alder reaction between acrolein and 1-benzyloxymethyl-1,3-cyclohexadiene affords a bicyclic aldehyde that was… Expand
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2009
2009
Within 1 year, platencin, a recently discovered antibiotic, has become a highly competitive synthetic target, due to its… Expand
Highly Cited
2008
Highly Cited
2008
A short and efficient synthesis of enone 3, a key intermediate in the total synthesis of platencin (2), based on an… Expand
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2008
2008
The readily available and enantiomerically pure trienes 12 undergo a thermally induced intramolecular Diels-Alder reaction to… Expand
Highly Cited
2007
Highly Cited
2007
Emergence of bacterial resistance is a major issue for all classes of antibiotics; therefore, the identification of new classes… Expand
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