plasminogen activator activity

OBSOLETE. Catalysis of the specific cleavage of an Arg-Val bond in plasminogen to form plasmin. [EC:3.4.21.68, EC:3.4.21.73]
National Institutes of Health

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AnistreplasePLAT protein, humanPlasminogen ActivatorReteplase
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Papers overview

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2009
2009
Plasminogen activator activity is inhibited while neuroserpin is up-regulated in the Alzheimer disease brain.
Amyloid-beta plaques are a pathological hallmark of Alzheimer's disease. Several proteases are known to cleave/remove amyloid… (More)
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2000
2000
Clinical significance of urokinase-type plasminogen activator activity in hepatocellular carcinoma.
BACKGROUND AND METHODS The plasminogen activation system plays a crucial role in the process of cancer invasion and metastasis… (More)
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Highly Cited
1999
Highly Cited
1999
Moderate alcohol intake and lower risk of coronary heart disease: meta-analysis of effects on lipids and haemostatic factors.
OBJECTIVE To summarise quantitatively the association between moderate alcohol intake and biological markers of risk of coronary… (More)
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1999
1999
The plasminogen activator inhibitor-1 gene, hypofibrinolysis, and osteonecrosis.
In 59 patients with osteonecrosis of the hip, four genes associated with thrombophilia or hypofibrinolysis along with coagulation… (More)
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Highly Cited
1995
Highly Cited
1995
Plasminogen activator and plasminogen activator inhibitor I release during experimental endotoxaemia in chimpanzees: effect of interventions in the cytokine and coagulation cascades.
1. Disseminated intravascular coagulation frequently accompanies Gram-negative sepsis and may contribute to widespread deposition… (More)
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Highly Cited
1994
Highly Cited
1994
Inhibition of endotoxin-induced activation of coagulation and fibrinolysis by pentoxifylline or by a monoclonal anti-tissue factor antibody in chimpanzees.
Knowledge of the pathogenetic mechanisms responsible for the activation of the coagulation system associated with endotoxemia is… (More)
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Highly Cited
1991
Highly Cited
1991
Lipoprotein (a) regulates plasminogen activator inhibitor-1 expression in endothelial cells. A potential mechanism in thrombogenesis.
Lipoprotein (a) (Lp(a)) is a low density lipoprotein-like particle which contains the plasminogen-like apolipoprotein a. Lp(a… (More)
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1986
1986
Autonomous functions of structural domains on human tissue-type plasminogen activator.
Transfected mouse Ltk- cells were employed for transient expression of recombinant human tissue-type plasminogen activator (t-PA… (More)
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Highly Cited
1984
Highly Cited
1984
Bioactivities, estrogen receptor interactions, and plasminogen activator-inducing activities of tamoxifen and hydroxy-tamoxifen isomers in MCF-7 human breast cancer cells.
Tamoxifen is used widely in the treatment of endocrine-responsive breast cancers in humans. Studies were undertaken to examine… (More)
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1982
1982
Plasminogen activator activity and composition in human breast cancer.
The plasminogen activator activity of human breast tumors was determined quantitatively in extracts of 33 primary tumors, 11… (More)
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