pixantrone

Known as: 6,9-bis((2-aminoethyl)amino)benzo(g)isoquinoline-5,10-dione, 6,9-AEA-BIQDO, 5,8-bis((2-aminoethyl)amino)-2-aza-anthracene-9,10-dione 
A synthetic, noncardiotoxic aza-anthracenedione analogue with potential antineoplastic activity. Pixantrone intercalates into DNA and induces… (More)

Topic mentions per year

Topic mentions per year

1978-2017
0102019782017

Papers overview

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Highly Cited
2007
Highly Cited
2007
In response to alphabeta1 integrin signaling, transducers such as focal adhesion kinase (FAK) become activated, relaying to… (More)
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Highly Cited
2005
Highly Cited
2005
Three of seven recently identified genes mutated in nonsyndromic mental retardation are involved in Rho family signaling. Two of… (More)
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Highly Cited
2005
Highly Cited
2005
Previously, we showed PAK-PIX-GIT targets and regulates focal adhesions; here, we uncover a different function for the complex at… (More)
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Highly Cited
2003
Highly Cited
2003
Efficient chemotaxis requires directional sensing and cell polarization. We describe a signaling mechanism involving G beta gamma… (More)
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Highly Cited
2003
Highly Cited
2003
The Shank/ProSAP family of multidomain proteins is known to play an important role in organizing synaptic multiprotein complexes… (More)
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Highly Cited
2001
Highly Cited
2001
The p21-activated kinases (PAKs), in common with many kinases, undergo multiple autophosphorylation events upon interaction with… (More)
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Highly Cited
2000
Highly Cited
2000
The p21-activated kinase PAK is targeted to focal complexes (FCs) through interactions with the SH3 domains of the PAK… (More)
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Highly Cited
2000
Highly Cited
2000
he integrins comprise a large family of transmembrane adhesion proteins and are each composed of an α and a β subunit. Humans… (More)
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Highly Cited
1999
Highly Cited
1999
Paxillin is a focal adhesion adaptor protein involved in the integration of growth factor- and adhesion-mediated signal… (More)
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Highly Cited
1998
Highly Cited
1998
The PAK family of kinases are regulated through interaction with the small GTPases Cdc42 and Rac1, but little is known of the… (More)
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