pitrakinra
National Institutes of Health
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Antagonising the IL-4 receptor α (IL-4Rα) interferes with downstream IL-4/IL-13 signalling and clinically has beneficial effects…
Asthma is a chronic inflammatory condition of the airways characterized by reversible airway obstruction, airway…
BackgroundAnimal models of human inflammatory diseases have limited predictive quality for human clinical trials for various…
Aeroallergens are the most common triggers for the development of asthma. Recent birth cohort studies have identified viral…
In asthma, airway inflammation is driven by Th2-related cytokines, such as IL-4, IL-5 and IL-13. IL-4 and IL-13, in particular…
Importance of the field: In asthma IL-4 and IL-13 have been demonstrated to play major pathogenic roles and therefore their…
Background: Pitrakinra is a recombinant protein derived from human interleukin‐4 (IL‐4) that binds to IL‐4Rα and acts as a…
Pitrakinra, a 15‐kDa recombinant human interleukin‐4 mutein, targets allergic Th2 inflammation by competitively binding to…