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pitrakinra

 
National Institutes of Health

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Interleukin-4

Papers overview

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Highly Cited
2012
Highly Cited
2012
IL-4 receptor polymorphisms predict reduction in asthma exacerbations during response to an anti-IL-4 receptor α antagonist.
BACKGROUND This is the first large pharmacogenetic investigation of the inflammatory IL-4/IL-13 pathway in patients with moderate… Expand
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2012
2012
Antagonism of cytokine-induced eosinophil accumulation in asthma
  • G. Walsh
  • Front. Pharmacol.
  • 2012
    • Corpus ID: 9164251
Asthma is a chronic inflammatory condition of the airways characterized by reversible airway obstruction, airway… Expand
2012
2012
NOD-scid IL2R γnull mice engrafted with human peripheral blood mononuclear cells as a model to test therapeutics targeting human signaling pathways
BackgroundAnimal models of human inflammatory diseases have limited predictive quality for human clinical trials for various… Expand
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Review
2012
Review
2012
The pharmacological modulation of allergen-induced asthma
Aeroallergens are the most common triggers for the development of asthma. Recent birth cohort studies have identified viral… Expand
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2010
2010
Pitrakinra, a dual IL-4/IL-13 antagonist for the potential treatment of asthma and eczema.
  • S. Antoniu
  • Current opinion in investigational drugs
  • 2010
    • Corpus ID: 37733142
In asthma, airway inflammation is driven by Th2-related cytokines, such as IL-4, IL-5 and IL-13. IL-4 and IL-13, in particular… Expand
2010
2010
Inhaled vs subcutaneous effects of a dual IL‐4/IL‐13 antagonist in a monkey model of asthma
Background:  Pitrakinra is a recombinant protein derived from human interleukin‐4 (IL‐4) that binds to IL‐4Rα and acts as a… Expand
Review
2010
Review
2010
Pitrakinra for asthma
Importance of the field: In asthma IL-4 and IL-13 have been demonstrated to play major pathogenic roles and therefore their… Expand
Highly Cited
2009
Highly Cited
2009
Human Pharmacokinetics/Pharmacodynamics of an Interleukin‐4 and Interleukin‐13 Dual Antagonist in Asthma
Pitrakinra, a 15‐kDa recombinant human interleukin‐4 mutein, targets allergic Th2 inflammation by competitively binding to… Expand
2008
2008
Gateways to clinical trials.
Gateways to Clinical Trials are a guide to the most recent clinical trials in current literature and congresses. The data in the… Expand
Highly Cited
2007
Highly Cited
2007
Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: results of two phase 2a studies
BACKGROUND Increases in T helper (Th) 2 cytokine concentrations have been seen in atopic asthma, with interleukin 4 and… Expand
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