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pitrakinra

 
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
BACKGROUND This is the first large pharmacogenetic investigation of the inflammatory IL-4/IL-13 pathway in patients with moderate… Expand
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2012
2012
  • G. Walsh
  • Front. Pharmacol.
  • 2012
  • Corpus ID: 9164251
Asthma is a chronic inflammatory condition of the airways characterized by reversible airway obstruction, airway… Expand
2012
2012
BackgroundAnimal models of human inflammatory diseases have limited predictive quality for human clinical trials for various… Expand
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Review
2012
Review
2012
Aeroallergens are the most common triggers for the development of asthma. Recent birth cohort studies have identified viral… Expand
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2010
2010
  • S. Antoniu
  • Current opinion in investigational drugs
  • 2010
  • Corpus ID: 37733142
In asthma, airway inflammation is driven by Th2-related cytokines, such as IL-4, IL-5 and IL-13. IL-4 and IL-13, in particular… Expand
2010
2010
Background:  Pitrakinra is a recombinant protein derived from human interleukin‐4 (IL‐4) that binds to IL‐4Rα and acts as a… Expand
Review
2010
Review
2010
Importance of the field: In asthma IL-4 and IL-13 have been demonstrated to play major pathogenic roles and therefore their… Expand
Highly Cited
2009
Highly Cited
2009
Pitrakinra, a 15‐kDa recombinant human interleukin‐4 mutein, targets allergic Th2 inflammation by competitively binding to… Expand
2008
2008
Gateways to Clinical Trials are a guide to the most recent clinical trials in current literature and congresses. The data in the… Expand
Highly Cited
2007
Highly Cited
2007
BACKGROUND Increases in T helper (Th) 2 cytokine concentrations have been seen in atopic asthma, with interleukin 4 and… Expand
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