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pitrakinra

National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Antagonising the IL-4 receptor α (IL-4Rα) interferes with downstream IL-4/IL-13 signalling and clinically has beneficial effects… 
Highly Cited
2012
2012
2012
  • G. Walsh
  • Front. Pharmacol.
  • 2012
  • Corpus ID: 9164251
Asthma is a chronic inflammatory condition of the airways characterized by reversible airway obstruction, airway… 
2012
2012
BackgroundAnimal models of human inflammatory diseases have limited predictive quality for human clinical trials for various… 
Review
2012
Review
2012
Aeroallergens are the most common triggers for the development of asthma. Recent birth cohort studies have identified viral… 
2010
2010
  • S. Antoniu
  • Current opinion in investigational drugs
  • 2010
  • Corpus ID: 37733142
In asthma, airway inflammation is driven by Th2-related cytokines, such as IL-4, IL-5 and IL-13. IL-4 and IL-13, in particular… 
Review
2010
Review
2010
Importance of the field: In asthma IL-4 and IL-13 have been demonstrated to play major pathogenic roles and therefore their… 
2010
2010
Background:  Pitrakinra is a recombinant protein derived from human interleukin‐4 (IL‐4) that binds to IL‐4Rα and acts as a… 
Highly Cited
2009
Highly Cited
2009
Pitrakinra, a 15‐kDa recombinant human interleukin‐4 mutein, targets allergic Th2 inflammation by competitively binding to…