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pirazolac

Known as: 4-(4-chlorophenyl)-1-(4-fluorophenyl)pyrazole-3-acetic acid 
National Institutes of Health

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Broader (1)

Pyrazoles

Papers overview

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2010
2010
Pharmacokinetics of pirazolac — A new anti-inflammatory drug — in human volunteers I. Absorption, disposition, biotransformation and excretion
SummaryThe absorption, disposition, biotransformation and excretion of the nonsteroidal anti-inflammatory drug pirazolac were… 
2004
2004
Transsynovial distribution and protein binding of pirazolac in patients with rheumatoid arthritis
SummaryFollowing a washout period of 7 days, twenty-one patients suffering from rheumatoid arthritis and 3 from osteo-arthritis… 
1990
1990
A 12-week double-blind study of the efficacy, safety and tolerance of pirazolac b.i.d. compared with indomethacin t.i.d. in patients with ankylosing spondylitis.
A 12-week trial was carried out to compare the efficacy of pirazolac (300-600 mg b.i.d.) with that of indomethacin (25-50 mg t.i… 
1990
1990
The pharmacokinetics of pirazolac in human subjects.
Pirazolac (PAA) is a new non-steroidal anti-inflammatory drug (NSAID) belonging to the subgroup of heterocyclic acetic acids. PAA… 
1990
1990
Multicentre double-blind study of the efficacy, safety and tolerance of pirazolac compared with sulindac in patients with rheumatoid arthritis.
Of the 160 patients (80 pirazolac/80 sulindac) who entered the study through 14 investigators, three-quarters completed a 12… 
1990
1990
Neutrophil functional and arachidonic acid metabolic correlates and clinical disease activity in pirazolac-treated rheumatoid arthritis patients.
Neutrophils from 20 medication-free rheumatoid arthritis patients were chemotactically hyporesponsive to 2 x 10(-8) M formyl… 
1987
1987
Effects of pirazolac on arachidonic acid metabolism in the human synovial system.
Six patients suffering from rheumatoid arthritis with massive knee joint effusions were treated with single daily doses of 600 mg… 
1985
1985
Pharmacokinetics of Pirazolac – a New Anti-Inflammatory Drug – in Human Volunteers II. Dose Linearity of Plasma Levels and Excretion
The concentration-time course of pirazolac in plasma and its urinary excretion were investigated in 6 young volunteers (3 males… 
1985
1985
Differential dosing study of pirazolac, a new non-steroidal anti-inflammatory agent, in patients with rheumatoid arthritis.
Twenty-four patients with classical or definite rheumatoid arthritis participated in a 4-week double-blind crossover study to… 
1985
1985
Comparison of occult blood loss caused by pirazolac and diclofenac sodium: a double-blind crossover study.
A study was carried out in 10 healthy subjects to compare the faecal blood loss caused by pirazolac, a new non-steroidal anti… 
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