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picromycin
Known as:
pikromycin
National Institutes of Health
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Related topics
Related topics
1 relation
Broader (1)
Macrolides
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2015
Highly Cited
2015
Enzymatic hydroxylation of an unactivated methylene C–H bond guided by molecular dynamics simulations
Alison R. H. Narayan
,
G. Jiménez‐Osés
,
+11 authors
D. Sherman
Nature Chemistry
2015
Corpus ID: 20626989
The hallmark of enzymes from secondary metabolic pathways is the pairing of powerful reactivity with exquisite site selectivity…
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Highly Cited
2014
Highly Cited
2014
Structural rearrangements of a polyketide synthase module during its catalytic cycle
J. R. Whicher
,
S. Dutta
,
+8 authors
G. Skiniotis
Nature
2014
Corpus ID: 4450674
The polyketide synthase (PKS) mega-enzyme assembly line uses a modular architecture to synthesize diverse and bioactive natural…
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Highly Cited
2007
Highly Cited
2007
Engineering and analysis of a self-sufficient biosynthetic cytochrome P450 PikC fused to the RhFRED reductase domain.
Shengying Li
,
L. Podust
,
D. Sherman
Journal of the American Chemical Society
2007
Corpus ID: 207045390
Cytochrome P450 enzymes mediate important oxidative processes in biological systems including regio- and stereospecific…
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Highly Cited
2006
Highly Cited
2006
The Structural Basis for Substrate Anchoring, Active Site Selectivity, and Product Formation by P450 PikC from Streptomyces venezuelae*
D. Sherman
,
Shengying Li
,
+4 authors
L. Podust
Journal of Biological Chemistry
2006
Corpus ID: 46696357
The pikromycin (Pik)/methymycin biosynthetic pathway of Streptomyces venezuelae represents a valuable system for dissecting the…
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Highly Cited
2005
Highly Cited
2005
Polyketide double bond biosynthesis. Mechanistic analysis of the dehydratase-containing module 2 of the picromycin/methymycin polyketide synthase.
Jiaquan Wu
,
Toby J Zaleski
,
C. Valenzano
,
C. Khosla
,
D. Cane
Journal of the American Chemical Society
2005
Corpus ID: 25230511
Picromycin/methymycin synthase (PICS) is a modular polyketide synthase (PKS) that is responsible for the biosynthesis of both 10…
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Highly Cited
2004
Highly Cited
2004
Characterization of the glycosyltransferase activity of desVII: analysis of and implications for the biosynthesis of macrolide antibiotics.
S. Borisova
,
Lishan Zhao
,
Charles E Melançon Iii
,
C. Kao
,
Hung‐wen Liu
Journal of the American Chemical Society
2004
Corpus ID: 21424934
In vitro catalytic activity of DesVII, the glycosyltransferase involved in the biosynthesis of methymycin, neomethymycin…
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Highly Cited
2001
Highly Cited
2001
Characterization and Analysis of the PikD Regulatory Factor in the Pikromycin Biosynthetic Pathway ofStreptomyces venezuelae
Daniel J. Wilson
,
Yongquan Xue
,
K. Reynolds
,
D. Sherman
Journal of bacteriology
2001
Corpus ID: 11441284
ABSTRACT The Streptomyces venezuelae pikD gene from the pikromycin biosynthetic cluster was analyzed, and its deduced product…
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Highly Cited
1999
Highly Cited
1999
Mechanism and specificity of the terminal thioesterase domain from the erythromycin polyketide synthase.
R. Gokhale
,
D. Hunziker
,
D. Cane
,
C. Khosla
Chemistry & biology
1999
Corpus ID: 28366718
Review
1998
Review
1998
A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae: architecture of metabolic diversity.
Y. Xue
,
L. Zhao
,
H. W. Liu
,
D. H. Sherman
Proceedings of the National Academy of Sciences…
1998
Corpus ID: 7977287
In a survey of microbial systems capable of generating unusual metabolite structural variability, Streptomyces venezuelae ATCC…
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Highly Cited
1998
Highly Cited
1998
Hydroxylation of macrolactones YC-17 and narbomycin is mediated by the pikC-encoded cytochrome P450 in Streptomyces venezuelae.
Yongquan Xue
,
Daniel J. Wilson
,
Lishan Zhao
,
Hung‐wen Liu
,
D. Sherman
Chemistry & biology
1998
Corpus ID: 20486265
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