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picromycin

Known as: pikromycin 
National Institutes of Health

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Related topics

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Broader (1)

Macrolides

Papers overview

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Highly Cited
2015
Highly Cited
2015
Enzymatic hydroxylation of an unactivated methylene C–H bond guided by molecular dynamics simulations
The hallmark of enzymes from secondary metabolic pathways is the pairing of powerful reactivity with exquisite site selectivity… 
Highly Cited
2014
Highly Cited
2014
Structural rearrangements of a polyketide synthase module during its catalytic cycle
The polyketide synthase (PKS) mega-enzyme assembly line uses a modular architecture to synthesize diverse and bioactive natural… 
Highly Cited
2007
Highly Cited
2007
Engineering and analysis of a self-sufficient biosynthetic cytochrome P450 PikC fused to the RhFRED reductase domain.
Cytochrome P450 enzymes mediate important oxidative processes in biological systems including regio- and stereospecific… 
Highly Cited
2006
Highly Cited
2006
The Structural Basis for Substrate Anchoring, Active Site Selectivity, and Product Formation by P450 PikC from Streptomyces venezuelae*
The pikromycin (Pik)/methymycin biosynthetic pathway of Streptomyces venezuelae represents a valuable system for dissecting the… 
Highly Cited
2005
Highly Cited
2005
Polyketide double bond biosynthesis. Mechanistic analysis of the dehydratase-containing module 2 of the picromycin/methymycin polyketide synthase.
Picromycin/methymycin synthase (PICS) is a modular polyketide synthase (PKS) that is responsible for the biosynthesis of both 10… 
Highly Cited
2004
Highly Cited
2004
Characterization of the glycosyltransferase activity of desVII: analysis of and implications for the biosynthesis of macrolide antibiotics.
In vitro catalytic activity of DesVII, the glycosyltransferase involved in the biosynthesis of methymycin, neomethymycin… 
Highly Cited
2001
Highly Cited
2001
Characterization and Analysis of the PikD Regulatory Factor in the Pikromycin Biosynthetic Pathway ofStreptomyces venezuelae
ABSTRACT The Streptomyces venezuelae pikD gene from the pikromycin biosynthetic cluster was analyzed, and its deduced product… 
Highly Cited
1999
Highly Cited
1999
Mechanism and specificity of the terminal thioesterase domain from the erythromycin polyketide synthase.
Review
1998
Review
1998
A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae: architecture of metabolic diversity.
In a survey of microbial systems capable of generating unusual metabolite structural variability, Streptomyces venezuelae ATCC… 
Highly Cited
1998
Highly Cited
1998
Hydroxylation of macrolactones YC-17 and narbomycin is mediated by the pikC-encoded cytochrome P450 in Streptomyces venezuelae.
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