picotamide

Known as: 4-methoxy-N,N'-bis(3-pyridinylmethyl)-1,3-benzenedicarboxamide 
 
National Institutes of Health

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Phthalic AcidsPlatelet Aggregation Inhibitors

Papers overview

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2013
2013
The receptor antagonist picotamide inhibits adrenergic and thromboxane-induced contraction of hyperplastic human prostate smooth muscle.
Inhibition of prostate smooth muscle contraction is an important strategy for medical treatment of lower urinary tract symptoms… (More)
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2004
2004
Picotamide in migraine aura prevention: a pilot study
In an open, preliminary trial we evaluated the use of picotamide, an antiplatelet drug, in the prophylactic treatment of migraine… (More)
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2004
2004
Picotamide, a combined inhibitor of thromboxane A2 synthase and receptor, reduces 2-year mortality in diabetics with peripheral arterial disease: the DAVID study.
AIMS Patients with diabetes are at excessive risk of mortality and cardiovascular morbidity. Previous studies suggest that… (More)
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1999
1999
Physical characterization of picotamide monohydrate and anhydrous picotamide.
Picotamide is an antiplatelet agent given by mouth as monohydrate (PICOW) (Plactidil) in thrombo-embolic disorders. This study… (More)
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1998
1998
Long-term treatment with the dual antithromboxane agent picotamide decreases microalbuminuria in normotensive type 2 diabetic patients.
Picotamide both inhibits thromboxane synthetase and acts as a thromboxane antagonist at the receptor level. We investigated the… (More)
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1997
1997
The effects of thromboxane A2 inhibition (picotamide) and angiotensin II receptor blockade (losartan) in primary Raynaud's phenomenon.
OBJECTIVES To assess the role of thromboxane A2 and of angiotensin II in patients with primary Raynaud's phenomenon. DESIGN… (More)
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1994
1994
Binding kinetics and antiplatelet activities of picotamide, a thromboxane A2 receptor antagonist.
1. Picotamide was shown to inhibit platelet binding of thromboxane A2 (TxA2)-mimetics and to cause a reduction of TxA2 platelet… (More)
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1993
1993
Effect of picotamide on the clinical progression of peripheral vascular disease. A double-blind placebo-controlled study. The ADEP Group.
BACKGROUND Patients with peripheral vascular disease (PVD) undergo a clinical course that can be complicated by cardiovascular… (More)
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1991
1991
In vitro effects of picotamide on human platelet aggregation, the release reaction and thromboxane B2 production.
We studied the in vitro effects of picotamide (N,N' bis 3 picolyl-4-methoxy-isophthalamide) on human platelet aggregation, the… (More)
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1989
1989
Competitive inhibition of platelet thromboxane A2 receptor binding by picotamide.
On the basis of indirect pharmacological evidence, picotamide, a methoxy derivative of 4-hydroxy-isophthalic acid (N,N'bis(3… (More)
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