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phthiocerol biosynthetic process

Known as: phthiocerol formation, phthiocerol biosynthesis, phthiocerol synthesis 
The chemical reactions and pathways resulting in the formation of phthiocerol, a lipid-based 1,3-glycol consisting of (3S,4R)-3-methoxy-4… Expand
National Institutes of Health

Papers overview

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2017
2017
Down-regulation of PE11, a cell wall associated esterase, enhances the biofilm growth of Mycobacterium tuberculosis and reduces cell wall virulence lipid levels.
PE11 (Rv1169c or LipX) is a cell wall associated esterase/lipase of Mycobacterium tuberculosis (Mtb). Evidences suggest that PE11… Expand
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2016
2016
Down-regulation of PE11, a cell wall associated esterase enhances the biofilm growth of Mycobacterium tuberculosis and reduces cell wall virulence lipid levels.
PE11 (Rv1169c or LipX) is a cell wall associated esterase/lipase of Mycobacterium tuberculosis(Mtb). Evidences suggest that PE11… Expand
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Highly Cited
2014
Highly Cited
2014
Mycobacteria manipulate macrophage recruitment through coordinated use of membrane lipids
The evolutionary survival of Mycobacterium tuberculosis, the cause of human tuberculosis, depends on its ability to invade the… Expand
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2013
2013
Disruption of the serine/threonine protein kinase H affects phthiocerol dimycocerosates synthesis in Mycobacterium tuberculosis
Mycobacterium tuberculosis possesses a complex cell wall that is unique and essential for interaction of the pathogen with its… Expand
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2013
2013
Analysis of Metabolic Evolution in Bacteria Using Whole-Genome Metabolic Models
Recent advances in the automation of metabolic model reconstruction have led to the availability of draft-quality metabolic… Expand
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2005
2005
Identification of phthiodiolone ketoreductase, an enzyme required for production of mycobacterial diacyl phthiocerol virulence factors.
Diacyl phthiocerol esters and their congeners are mycobacterial virulence factors. The biosynthesis of these complex lipids… Expand
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2004
2004
Mycobacterium tuberculosis defective in phthiocerol dimycocerosate translocation provides greater protective immunity against tuberculosis than the existing bacille Calmette-Guérin vaccine.
We demonstrate that Mycobacterium tuberculosis that is unable to export the complex lipid phthiocerol dimycocerosate has a… Expand
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2003
2003
Virulence attenuation of two Mas-like polyketide synthase mutants of Mycobacterium tuberculosis.
The cell envelope of pathogenic mycobacteria is highly distinctive in that it contains a large number of structurally related… Expand
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Highly Cited
2002
Highly Cited
2002
Role of the pks15/1 gene in the biosynthesis of phenolglycolipids in the Mycobacterium tuberculosis complex. Evidence that all strains synthesize glycosylated p-hydroxybenzoic methyl esters and that…
Diesters of phthiocerol and phenolphthiocerol are important virulence factors of Mycobacterium tuberculosis and Mycobacterium… Expand
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1985
1985
Distribution of some mycobacterial waxes based on the phthiocerol family.
Characteristic waxes, based on methoxy and keto long-chain diols, members of the phthiocerol family, have been isolated from… Expand
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