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phthiocerol biosynthetic process

Known as: phthiocerol formation, phthiocerol biosynthesis, phthiocerol synthesis 
The chemical reactions and pathways resulting in the formation of phthiocerol, a lipid-based 1,3-glycol consisting of (3S,4R)-3-methoxy-4… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1959-2018
02419592018

Papers overview

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Highly Cited
2014
Highly Cited
2014
Mycobacteria manipulate macrophage recruitment through coordinated use of membrane lipids
The evolutionary survival of Mycobacterium tuberculosis, the cause of human tuberculosis, depends on its ability to invade the… (More)
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Highly Cited
2010
Highly Cited
2010
Variation among genome sequences of H37Rv strains of Mycobacterium tuberculosis from multiple laboratories.
The publication of the complete genome sequence for Mycobacterium tuberculosis H37Rv in 1998 has had a great impact on the… (More)
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2009
2009
Rapid and spontaneous loss of phthiocerol dimycocerosate (PDIM) from Mycobacterium tuberculosis grown in vitro: implications for virulence studies.
Isolated in vitro more than half a century ago, the H37Rv strain of Mycobacterium tuberculosis still remains the strain of choice… (More)
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Highly Cited
2009
Highly Cited
2009
Mycobacterium tuberculosis WhiB3 Maintains Redox Homeostasis by Regulating Virulence Lipid Anabolism to Modulate Macrophage Response
The metabolic events associated with maintaining redox homeostasis in Mycobacterium tuberculosis (Mtb) during infection are… (More)
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2009
2009
Phthiocerol dimycocerosate transport is required for resisting interferon-gamma-independent immunity.
Nitric oxide (NO), which is an important component of immunity to Mycobacterium tuberculosis, has both cytotoxic and immune… (More)
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2005
2005
Transposon mutagenesis of Mb0100 at the ppe1-nrp locus in Mycobacterium bovis disrupts phthiocerol dimycocerosate (PDIM) and glycosylphenol-PDIM biosynthesis, producing an avirulent strain with…
The unusual and complex cell wall of pathogenic mycobacteria plays a major role in pathogenesis, with specific complex lipids… (More)
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Highly Cited
2004
Highly Cited
2004
Production of phthiocerol dimycocerosates protects Mycobacterium tuberculosis from the cidal activity of reactive nitrogen intermediates produced by macrophages and modulates the early immune…
The growth of Mycobacterium tuberculosis mutants unable to synthesize phthiocerol dimycocerosates (DIMs) was recently shown to be… (More)
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2004
2004
Molecular dissection of the role of two methyltransferases in the biosynthesis of phenolglycolipids and phthiocerol dimycoserosate in the Mycobacterium tuberculosis complex.
A few mycobacterial species, most of which are pathogenic for humans, produce dimycocerosates of phthiocerol (DIM) and of… (More)
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2003
2003
The largest open reading frame (pks12) in the Mycobacterium tuberculosis genome is involved in pathogenesis and dimycocerosyl phthiocerol synthesis.
The cell wall lipids in Mycobacterium tuberculosis are probably involved in pathogenesis. The largest open reading frame in the… (More)
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2003
2003
Attenuation of Mycobacterium tuberculosis by disruption of a mas-like gene or a chalcone synthase-like gene, which causes deficiency in dimycocerosyl phthiocerol synthesis.
Tuberculosis is one of the leading preventable causes of death. Emergence of drug-resistant tuberculosis makes the discovery of… (More)
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