phosphoinositide-3,4,5-triphosphate

Known as: PI(3,4,5)P3 
 

Topic mentions per year

Topic mentions per year

1992-2017
0102019922017

Papers overview

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Highly Cited
2007
Highly Cited
2007
Chemotaxing neutrophils and Dictyostelium amoebae produce in their plasma membranes the signaling lipid PI(3,4,5)P3 (PIP3) in… (More)
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Highly Cited
2004
Highly Cited
2004
In chemotaxing cells, localization of phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) to the leading edge of the cell sets… (More)
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Highly Cited
2003
Highly Cited
2003
Neutrophils exposed to chemoattractants polarize and accumulate polymerized actin at the leading edge. In neutrophil-like HL-60… (More)
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Highly Cited
2003
Highly Cited
2003
Recent studies have demonstrated that PH domains specific for PI(3,4,5)P3 accumulate at the leading edge of a number of migrating… (More)
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Highly Cited
2003
Highly Cited
2003
The directional movement of cells in chemoattractant gradients requires sophisticated control of the actin cytoskeleton. Uniform… (More)
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Highly Cited
2002
Highly Cited
2002
Shallow gradients of chemoattractants, sensed by G protein-linked signaling pathways, elicit localized binding of PH domains… (More)
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Highly Cited
1999
Highly Cited
1999
SHIP is an inositol 5' phosphatase that hydrolyzes the PI3'K product PI(3,4,5)P3. We show that SHIP-deficient mice exhibit… (More)
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Highly Cited
1999
Highly Cited
1999
Phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) has been proposed to act as a second messenger to recruit regulatory… (More)
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Highly Cited
1997
Highly Cited
1997
Cell attachment to fibronectin stimulates the integrin-dependent interaction of p85-associated phosphatidylinositol (PI) 3-kinase… (More)
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Highly Cited
1996
Highly Cited
1996
Pleckstrin homology (PH) domains may act as membrane localization modules through specific interactions with phosphoinositide… (More)
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