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phosphoinositide-3,4,5-triphosphate

Known as: PI(3,4,5)P3 
 
National Institutes of Health

Papers overview

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Highly Cited
2006
Highly Cited
2006
The phosphoinositide 3-kinase (PI3K)/Akt pathway is commonly activated in cancer; therefore, we investigated its role in hypoxia… Expand
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Highly Cited
2005
Highly Cited
2005
Polarity is a prominent feature of both chemotaxis and cytokinesis. In chemotaxis, polarity is established by local accumulation… Expand
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Highly Cited
2004
Highly Cited
2004
In chemotaxing cells, localization of phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) to the leading edge of the cell sets… Expand
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Highly Cited
2003
Highly Cited
2003
Neutrophils exposed to chemoattractants polarize and accumulate polymerized actin at the leading edge. In neutrophil-like HL-60… Expand
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Highly Cited
2003
Highly Cited
2003
Recent studies have demonstrated that PH domains specific for PI(3,4,5)P3 accumulate at the leading edge of a number of migrating… Expand
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Highly Cited
2002
Highly Cited
2002
Shallow gradients of chemoattractants, sensed by G protein-linked signaling pathways, elicit localized binding of PH domains… Expand
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Highly Cited
2002
Highly Cited
2002
Using bone marrow derived mast cells from SH2-containing inositol-5-phosphatase (SHIP) +/+ and −/− mice, we found that the loss… Expand
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Highly Cited
2001
Highly Cited
2001
Initially identified in high-grade gliomas, mutations in the PTEN tumor-suppressor are also found in many sporadic cancers and a… Expand
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Highly Cited
2001
Highly Cited
2001
Phosphatidylinositol (PI) 3-kinase plays an important role in various metabolic actions of insulin including glucose uptake and… Expand
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Highly Cited
1996
Highly Cited
1996
Listeria monocytogenes is a bacterial pathogen that invades cultured nonphagocytic cells. Inhibitors and a dominant negative… Expand
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