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phosphoinositidase C

Known as: Phosphatidylinositol Phospholipase C, PLC-Gamma-1, Triphosphoinositide Phosphodiesterase 
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (1290 aa, ~149 kDa) is encoded by the human PLCG1 gene. This protein is involved in… Expand
National Institutes of Health

Related topics

Related topics

36 relations
Angiogenesis PathwayAngiotensin II Signaling PathwayB Cell Receptor Signaling PathwayC2 Domains
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Broader (1)

glycerophosphoinositol glycerophosphodiesterase

Papers overview

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Highly Cited
2014
Highly Cited
2014
PLCG1 mutations in cutaneous T-cell lymphomas.
Cutaneous T-cell lymphoma (CTCL) is a heterogeneous group of primary cutaneous T-cell lymphoproliferative processes, mainly… Expand
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Highly Cited
2006
Highly Cited
2006
Activation of Abl tyrosine kinases promotes invasion of aggressive breast cancer cells.
The Abl family of nonreceptor tyrosine kinases consists of two related proteins, c-Abl and Abl-related gene (Arg). Activated… Expand
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Highly Cited
2002
Highly Cited
2002
Angiogenic Oligosaccharides of Hyaluronan Induce Multiple Signaling Pathways Affecting Vascular Endothelial Cell Mitogenic and Wound Healing Responses*
Hyaluronan (HA) is a large nonsulfated glycosaminoglycan and an important regulator of angiogenesis, in particular, the growth… Expand
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Highly Cited
2001
Highly Cited
2001
Vav1 Regulates Phospholipase Cγ Activation and Calcium Responses in Mast Cells
ABSTRACT The hematopoietic cell-specific protein Vav1 is a substrate of tyrosine kinases activated following engagement of many… Expand
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Review
1993
Review
1993
Fat cell adrenergic receptors and the control of white and brown fat cell function.
Five adrenoceptor subtypes are involved in the adrenergic regulation of white and brown fat cell function. The effects on cAMP… Expand
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Review
1993
Review
1993
Desensitization of cell signalling mediated by phosphoinositidase C.
The waning of responses to cell-surface receptor activation during persistent stimulation with agonists (desensitization) is a… Expand
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Highly Cited
1992
Highly Cited
1992
Nuclear localization and signalling activity of phosphoinositidase Cβ in Swiss 3T3 cells
THE hydrolysis of phosphatidylinositol 4,5-bisphosphate (PtdInsP2) is a widespread receptor-coupled signalling system at the… Expand
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Highly Cited
1992
Highly Cited
1992
Selective inhibition of phosphatidylinositol phospholipase C by cytotoxic ether lipid analogues.
The ether lipid analogue 1-octadecyl-2-methyl-rac-glycero-3-phosphocholine (ET-18-OCH3) has been shown to be a direct inhibitor… Expand
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Highly Cited
1989
Highly Cited
1989
EGF induces tyrosine phosphorylation of phospholipase C-II: A potential mechanism for EGF receptor signaling
Binding of EGF to cells expressing human EGF receptor stimulated rapid tyrosine phosphorylation of phospholipase C-II (PLC-II… Expand
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Highly Cited
1988
Highly Cited
1988
Sequence similarity of phospholipase C with the non-catalytic region of src
The production of the second messenger molecules diacylglycerol and inositol 1,4,5-trisphosphate1 is mediated by activated phos… Expand
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