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phosphoinositidase C
Known as:
Phosphatidylinositol Phospholipase C
, PLC-Gamma-1
, Triphosphoinositide Phosphodiesterase
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1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (1290 aa, ~149 kDa) is encoded by the human PLCG1 gene. This protein is involved in…
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National Institutes of Health
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Related topics
Related topics
36 relations
Angiogenesis Pathway
Angiotensin II Signaling Pathway
B Cell Receptor Signaling Pathway
C2 Domains
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Broader (1)
glycerophosphoinositol glycerophosphodiesterase
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
PLCG1 mutations in cutaneous T-cell lymphomas.
J. Vaqué
,
G. Gómez-López
,
+25 authors
M. Sánchez-Beato
Blood
2014
Corpus ID: 206921771
Cutaneous T-cell lymphoma (CTCL) is a heterogeneous group of primary cutaneous T-cell lymphoproliferative processes, mainly…
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Highly Cited
2006
Highly Cited
2006
Activation of Abl tyrosine kinases promotes invasion of aggressive breast cancer cells.
D. Srinivasan
,
R. Plattner
Cancer research
2006
Corpus ID: 33283295
The Abl family of nonreceptor tyrosine kinases consists of two related proteins, c-Abl and Abl-related gene (Arg). Activated…
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Highly Cited
2002
Highly Cited
2002
Angiogenic Oligosaccharides of Hyaluronan Induce Multiple Signaling Pathways Affecting Vascular Endothelial Cell Mitogenic and Wound Healing Responses*
M. Slevin
,
Shant Kumar
,
J. Gaffney
The Journal of Biological Chemistry
2002
Corpus ID: 22470535
Hyaluronan (HA) is a large nonsulfated glycosaminoglycan and an important regulator of angiogenesis, in particular, the growth…
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Highly Cited
2001
Highly Cited
2001
Mapping the Zap-70 phosphorylation sites on LAT (linker for activation of T cells) required for recruitment and activation of signalling proteins in T cells.
P. Paz
,
Su Wang
,
H. Clarke
,
X. Lu
,
D. Stokoe
,
A. Abo
The Biochemical journal
2001
Corpus ID: 8284885
T-cell-receptor (TCR)-mediated LAT (linker for activation of T cells) phosphorylation is critical for the membrane recruitment of…
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Review
1995
Review
1995
Phospholipid signaling
N. Divecha
,
R. Irvine
Cell
1995
Corpus ID: 14120598
Review
1993
Review
1993
Fat cell adrenergic receptors and the control of white and brown fat cell function.
M. Lafontan
,
M. Berlan
Journal of lipid research
1993
Corpus ID: 10208398
Five adrenoceptor subtypes are involved in the adrenergic regulation of white and brown fat cell function. The effects on cAMP…
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Highly Cited
1992
Highly Cited
1992
Nuclear localization and signalling activity of phosphoinositidase Cβ in Swiss 3T3 cells
A. Martelli
,
R. Gilmour
,
V. Bertagnolo
,
L. Neri
,
L. Manzoli
,
L. Cocco
Nature
1992
Corpus ID: 4308764
THE hydrolysis of phosphatidylinositol 4,5-bisphosphate (PtdInsP2) is a widespread receptor-coupled signalling system at the…
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Highly Cited
1992
Highly Cited
1992
Selective inhibition of phosphatidylinositol phospholipase C by cytotoxic ether lipid analogues.
G. Powis
,
M. Seewald
,
C. Gratas
,
D. Melder
,
J. Riebow
,
E. Modest
Cancer research
1992
Corpus ID: 30162457
The ether lipid analogue 1-octadecyl-2-methyl-rac-glycero-3-phosphocholine (ET-18-OCH3) has been shown to be a direct inhibitor…
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Highly Cited
1989
Highly Cited
1989
EGF induces tyrosine phosphorylation of phospholipase C-II: A potential mechanism for EGF receptor signaling
B. Margolis
,
S. Rhee
,
+6 authors
J. Schlessinger
Cell
1989
Corpus ID: 45800046
Highly Cited
1988
Highly Cited
1988
Sequence similarity of phospholipase C with the non-catalytic region of src
M. Stahl
,
C. Ferenz
,
K. Kelleher
,
R. Kriz
,
J. Knopf
Nature
1988
Corpus ID: 6347459
The production of the second messenger molecules diacylglycerol and inositol 1,4,5-trisphosphate1 is mediated by activated phos…
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