phosphoinositidase C

Known as: Phosphatidylinositol Phospholipase C, PLC-Gamma-1, Triphosphoinositide Phosphodiesterase 
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (1290 aa, ~149 kDa) is encoded by the human PLCG1 gene. This protein is involved in… (More)
National Institutes of Health

Related topics

Related topics

36 relations
Angiogenesis PathwayAngiotensin II Signaling PathwayB Cell Receptor Signaling PathwayC2 Domains
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Broader (1)

glycerophosphoinositol glycerophosphodiesterase

Papers overview

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Highly Cited
2006
Highly Cited
2006
Activation of Abl tyrosine kinases promotes invasion of aggressive breast cancer cells.
The Abl family of nonreceptor tyrosine kinases consists of two related proteins, c-Abl and Abl-related gene (Arg). Activated… (More)
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Highly Cited
2002
Highly Cited
2002
Angiogenic oligosaccharides of hyaluronan induce multiple signaling pathways affecting vascular endothelial cell mitogenic and wound healing responses.
Hyaluronan (HA) is a large nonsulfated glycosaminoglycan and an important regulator of angiogenesis, in particular, the growth… (More)
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Highly Cited
2002
Highly Cited
2002
Tr-kit-induced resumption of the cell cycle in mouse eggs requires activation of a Src-like kinase.
Microinjection in mouse eggs of tr-kit, a truncated form of the c-kit tyrosine kinase present in mouse spermatozoa, causes… (More)
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Highly Cited
2001
Highly Cited
2001
Mapping the Zap-70 phosphorylation sites on LAT (linker for activation of T cells) required for recruitment and activation of signalling proteins in T cells.
T-cell-receptor (TCR)-mediated LAT (linker for activation of T cells) phosphorylation is critical for the membrane recruitment of… (More)
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Highly Cited
2001
Highly Cited
2001
Vav1 regulates phospholipase cgamma activation and calcium responses in mast cells.
The hematopoietic cell-specific protein Vav1 is a substrate of tyrosine kinases activated following engagement of many receptors… (More)
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Review
1993
Review
1993
Fat cell adrenergic receptors and the control of white and brown fat cell function.
Five adrenoceptor subtypes are involved in the adrenergic regulation of white and brown fat cell function. The effects on cAMP… (More)
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1993
1993
Phosphoinositide signalling enzymes in rat liver nuclei: phosphoinositidase C isoform beta 1 is specifically, but not predominantly, located in the nucleus.
The presence of phosphoinositide-mobilizing enzymes has been investigated in purified rat liver nuclei by radiolabelling and by… (More)
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Highly Cited
1992
Highly Cited
1992
Nuclear localization and signalling activity of phosphoinositidase Cβ in Swiss 3T3 cells
THE hydrolysis of phosphatidylinositol 4,5-bisphosphate (PtdInsP2) is a widespread receptor-coupled signalling system at the… (More)
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Highly Cited
1992
Highly Cited
1992
Selective inhibition of phosphatidylinositol phospholipase C by cytotoxic ether lipid analogues.
The ether lipid analogue 1-octadecyl-2-methyl-rac-glycero-3-phosphocholine (ET-18-OCH3) has been shown to be a direct inhibitor… (More)
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Highly Cited
1988
Highly Cited
1988
Sequence similarity of phospholipase C with the non-catalytic region of src
The production of the second messenger molecules diacylglycerol and inositol 1,4,5-trisphosphate1 is mediated by activated phos… (More)
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