phosphodiester

 
National Institutes of Health

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Highly Cited
2013
Highly Cited
2013
The presence of microbial or self DNA in the cytoplasm of mammalian cells is a danger signal detected by the DNA sensor cyclic… (More)
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Review
2008
Review
2008
The Class III PI3K (phosphoinositide 3-kinase), Vps34 (vacuolar protein sorting 34), was first described as a component of the… (More)
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Highly Cited
2005
Highly Cited
2005
The mRNA-cleavage step of RNA interference is mediated by an endonuclease, Argonaute2 (Ago2), within the RNA-induced silencing… (More)
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Highly Cited
2004
Highly Cited
2004
Short interfering RNAs (siRNAs) are valuable tools for analyzing protein function in mammalian cell culture. This success has led… (More)
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Highly Cited
2004
Highly Cited
2004
Short RNAs mediate gene silencing, a process associated with virus resistance, developmental control and heterochromatin… (More)
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Highly Cited
2002
Highly Cited
2002
Solvent binding in the nucleosome core particle containing a 147 base pair, defined-sequence DNA is characterized from the X-ray… (More)
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Highly Cited
1996
Highly Cited
1996
Yeast cell wall proteins, including Cwp1p and alpha-agglutinin, could be released by treating the cell wall with either beta-1,3… (More)
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Highly Cited
1992
Highly Cited
1992
By using a human cell-free system capable of nucleotide excision repair, a synthetic substrate consisting of a plasmid containing… (More)
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Highly Cited
1990
Highly Cited
1990
Antisense oligodeoxynucleotides specific for sequences in mRNAs from the B-cell lymphoma/leukemia-2 (BCL2) gene were used to… (More)
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Highly Cited
1984
Highly Cited
1984
Adriamycin (doxorubicin), a potent antitumor drug in clinical use, interacts with nucleic acids and cell membranes, but the… (More)
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