phosphatidylinositol phospholipase C activity

Known as: 1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase activity, PI-PLC activity, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase activity 
Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1982-2017
051019822017

Papers overview

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2008
2008
Phospholipase B1 (Plb1) is secreted after release from its glycosylphosphatidylinositol anchor and is implicated in initiation… (More)
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Highly Cited
1999
Highly Cited
1999
Oscillations in cytosolic free Ca2+ concentration ([Ca2+]cyt) are an important component of Ca2+-based signal transduction… (More)
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1997
1997
Protein kinase C (PKC) is activated at the nucleus during the G2 phase of cell cycle, where it is required for mitosis. However… (More)
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1992
1992
The relative specificities of members of the G alpha q family of GTP-binding proteins were tested for their ability to activate… (More)
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1991
1991
A phosphatidylinositol-specific phospholipase C (PI-PLC) that is unique to the pathogenic Listeria species L. monocytogenes and L… (More)
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1991
1991
A phospholipase C which cleaves phosphatidylinositol and glycosylphosphatidylinositol (GPI) anchors was identified in Listeria… (More)
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Highly Cited
1991
Highly Cited
1991
A number of bacterial species secrete phosphatidylinositol-specific phospholipase C (PI-PLC). In this report, we show that the… (More)
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1991
1991
In this study, 468 Listeria strains were checked for the presence of phosphatidylinositol-specific phospholipase C (PI-PLC… (More)
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1990
1990
Phosphoinositide phospholipase C activity was investigated in human melanoma grown as solid tumor xenografts in nude mice. The… (More)
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1982
1982
Aminoglycosides are able to inhibit phosphatidylinositol phospholipase C activity in a soluble fraction of rat renal tissue. The… (More)
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