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phosphatidylinositol 3-kinase complex, class IA

Known as: class IA PI3K complex, phosphatidylinositol 3-kinase complex location, class IA, phosphoinositide 3-kinase complex, class IA 
A class I phosphatidylinositol 3-kinase complex that possesses 1-phosphatidylinositol-4-phosphate 3-kinase activity; comprises a catalytic class IA… Expand
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
Phosphinositide 3-kinase (PI3K), Akt, and their downstream kinase, mammalian target of rapamycin (mTOR), are implicated in neural… Expand
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Highly Cited
2010
Highly Cited
2010
p110-β associates with the Vps34–Vps15–Beclin 1–Atg14L complex and facilitates generation of PtdIns(3)P to promote autophagy. 
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Highly Cited
2009
Highly Cited
2009
Acquisition of a transformed phenotype involves deregulation of several signal transduction pathways contributing to… Expand
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Highly Cited
2008
Highly Cited
2008
Nephrin is a slit diaphragm protein critical for structural and functional integrity of visceral glomerular epithelial cells… Expand
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Highly Cited
2003
Highly Cited
2003
Background—We have recently shown that genetic inactivation of phosphoinositide 3-kinase &ggr; (PI3K&ggr;), the isoform linked to… Expand
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Highly Cited
2002
Highly Cited
2002
Endothelial nitric-oxide synthase (eNOS) is an important component of vascular homeostasis. During vascular disease, endothelial… Expand
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Highly Cited
2002
Highly Cited
2002
ABSTRACT Many receptor and nonreceptor tyrosine kinases activate phosphoinositide 3-kinases (PI3Ks). To assess the role of the… Expand
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Highly Cited
2002
Highly Cited
2002
Phosphoinositide 3-kinase (PI3-kinase)-dependent phosphorylation of the proapoptotic Bcl-2 family member Bad has been proposed as… Expand
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Highly Cited
1999
Highly Cited
1999
Phosphoinositide 3‐kinases (PI3Ks) are lipid kinases which also possess an in vitro protein kinase activity towards themselves or… Expand
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Highly Cited
1998
Highly Cited
1998
ErbB3 (HER3), a unique member of the ErbB receptor family, lacks intrinsic protein tyrosine kinase activity and contains six Tyr… Expand
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