phosphatidylinositol 3-kinase activity

Known as: phosphoinositide 3-kinase activity 
Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol 3-phosphate. This reaction is the addition of a phosphate… (More)
National Institutes of Health

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Highly Cited
2004
Highly Cited
2004
Depending on the cellular context, Ras can activate characteristic effectors by mechanisms still poorly understood. Promotion by… (More)
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Highly Cited
2002
Highly Cited
2002
Recent studies have demonstrated that fatty acids induce insulin resistance in skeletal muscle by blocking insulin activation of… (More)
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Highly Cited
2000
Highly Cited
2000
Previous studies have indicated that proapoptotic stresses downregulate the phosphatidylinositol 3-kinase [PI(3)K]/Akt survival… (More)
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Highly Cited
1999
Highly Cited
1999
To examine the mechanism by which free fatty acids (FFA) induce insulin resistance in human skeletal muscle, glycogen, glucose-6… (More)
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Highly Cited
1997
Highly Cited
1997
We examined the effect of physiological hyperinsulinemia on insulin receptor substrate-1 (IRS-1) tyrosine phosphorylation and… (More)
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Highly Cited
1996
Highly Cited
1996
Addition of wortmannin to normal rat kidney cells caused a redistribution of the lysosomal type I integral membrane proteins… (More)
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Highly Cited
1995
Highly Cited
1995
To determine whether the impaired insulin-stimulated glucose uptake in obese individuals is associated with altered insulin… (More)
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Highly Cited
1994
Highly Cited
1994
The Ras-like GTPase Cdc42 is essential for cell polarity and bud site assembly in Saccharomyces cerevisiae by regulating cell… (More)
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Highly Cited
1993
Highly Cited
1993
Insulin stimulates tyrosine phosphorylation of insulin receptor substrate 1 (IRS-1), which in turn binds to and activates… (More)
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Highly Cited
1992
Highly Cited
1992
Growth factors stimulate the enzyme phosphatidylinositol (PI) 3-kinase in cells in culture. Insulin rapidly stimulates tyrosine… (More)
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