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phosphatidylinositol 3-kinase activity

Known as: phosphoinositide 3-kinase activity 
Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol 3-phosphate. This reaction is the addition of a phosphate… Expand
National Institutes of Health

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Highly Cited
2005
Highly Cited
2005
To examine the molecular mechanisms by which plasma amino acid elevation impairs insulin action, we studied seven healthy men… Expand
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Highly Cited
2002
Highly Cited
2002
Recent studies have demonstrated that fatty acids induce insulin resistance in skeletal muscle by blocking insulin activation of… Expand
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Highly Cited
2000
Highly Cited
2000
ABSTRACT Previous studies have indicated that proapoptotic stresses downregulate the phosphatidylinositol 3-kinase [PI(3)K]/Akt… Expand
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Highly Cited
1999
Highly Cited
1999
To examine the mechanism by which free fatty acids (FFA) induce insulin resistance in human skeletal muscle, glycogen, glucose-6… Expand
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Highly Cited
1997
Highly Cited
1997
We examined the effect of physiological hyperinsulinemia on insulin receptor substrate-1 (IRS-1) tyrosine phosphorylation and… Expand
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Highly Cited
1995
Highly Cited
1995
To determine whether the impaired insulin-stimulated glucose uptake in obese individuals is associated with altered insulin… Expand
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Highly Cited
1994
Highly Cited
1994
The Ras-like GTPase Cdc42 is essential for cell polarity and bud site assembly in Saccharomyces cerevisiae by regulating cell… Expand
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Highly Cited
1994
Highly Cited
1994
SH-PTP2 is a nontransmembrane human protein-tyrosine phosphatase that contains two Src homology 2 (SH2) domains and binds to… Expand
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Highly Cited
1993
Highly Cited
1993
We identified a serine/threonine protein kinase that is associated with and phosphorylates phosphoinositide 3-kinase (PtdIns 3… Expand
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Highly Cited
1992
Highly Cited
1992
Growth factors stimulate the enzyme phosphatidylinositol (PI) 3-kinase in cells in culture. Insulin rapidly stimulates tyrosine… Expand
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