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phosphatidylinositol 3,4,5-triphosphate

Known as: 3,4,5-PIP3, PtdIns(3,4,5)P3, phosphatidylinositol 3,4,5-trisphosphate 
National Institutes of Health

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Phosphatidylinositol Phosphates

Papers overview

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2017
2017
PREX1 regulates ERK1/2 in breast cancer
PREX1 (PtdIns(3,4,5)P3-dependent Rac exchanger 1), is a Rac-GEF overexpressed in a significant proportion of human breast cancers… 
2014
2014
[Expression, purification and phosphoinositide binding specifity of recombinant human SNX7 expressed in Escherichia coli].
Sorting nexins (SNXs) are a large group of proteins that contain Phox (PX) domain and involve in regulating endocytosis and… 
2013
2013
Cross Talk between the Akt and p 38 Pathways in Macrophages Downstream of Toll-Like Receptor Signaling
Victoria A. McGuire, Alexander Gray, Claire E. Monk, Susana G. Santos, Keunwook Lee, Anna Aubareda, Jonathan Crowe, Natalia… 
2009
2009
FcyRIIB-mediated inhibition of T-cell receptor signal transduction involves the phosphorylation of SH 2-containing inositol 5-phosphatase ( SHIP ) , dephosphorylation of the linker of activated T…
T h e low-affinity receptor for immunoglobulin G , FcyRIIB, is expressed on most B-cells and on immature and activated mature T… 
2008
2008
Lipids: Orientating with PtdIns(3,4,5)P3
themselves before starting an ascent, so must cells orientate their spindles before division. But whereas mountaineers have… 
2007
2007
The role of SHIP 1 in T-lymphocyte life and death
SHIP1 [SH2 (Src homology 2)-containing inositol phosphatase-1], an inositol 5-phosphatase expressed in haemopoietic cells, acts… 
Review
2005
Review
2005
IDENTIFICATION OF P 122 RHOGAP ( D ELETED IN L IVER C ANCER-1 ) SERINE-322 AS A SUBSTRATE FOR PROTEIN KINASE B AND RSK IN INSULIN-STIMULATED CELLS
Protein kinase B (Akt) plays an essential role in the actions of insulin, cytokines and growth factors, although the substrates… 
2004
2004
A Novel PI 3-Kinase Assay Utilising HTRF ® Technology on the RUBYstar
Inositol phospholipids provide a wide range of cellular signals that play crucial roles in normal cell function. These lipids are… 
Review
2002
Review
2002
Indole-3-carbinol Inhibits Protein Kinase B / Akt and Induces Apoptosis in the Human Breast Tumor Cell Line MDA MB 468 but not in the Nontumorigenic HBL 100 Line 1
We have identified a new target for the chemopreventive dietary agent indole-3-carbinol (I3C) in the antiapoptotic signaling… 
Review
2000
Review
2000
Structural biology: Pocket the difference
There’s a molecular identity parade at the plasma membrane every time cells activate phosphatidylinositol 3-OH kinase (PI(3)K…