phosphatidylinositol 3,4,5-triphosphate

Known as: 3,4,5-PIP3, PtdIns(3,4,5)P3, phosphatidylinositol 3,4,5-trisphosphate 
 
National Institutes of Health

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Highly Cited
2010
Highly Cited
2010
In the developing nervous system, constitutive activation of the AKT/mTOR (mammalian target of rapamycin) pathway in myelinating… (More)
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Highly Cited
2006
Highly Cited
2006
Polarity is a central feature of eukaryotic cells and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) has a central… (More)
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Highly Cited
2004
Highly Cited
2004
Experiments in amoebae and neutrophils have shown that local accumulations of phosphatidylinositol 3,4,5-trisphosphate [PI(3,4,5… (More)
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Highly Cited
2002
Highly Cited
2002
The products of PI 3-kinase activation, PtdIns(3,4,5)P3 and its immediate breakdown product PtdIns(3,4)P2, trigger physiological… (More)
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Highly Cited
1999
Highly Cited
1999
3-Phosphoinositide-dependent protein kinase-1 (PDK1) interacts stereoselectively with the d-enantiomer of PtdIns(3,4,5)P3 (KD 1.6… (More)
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Highly Cited
1999
Highly Cited
1999
Phagocytosis requires actin assembly and pseudopod extension, two cellular events that coincide spatially and temporally. The… (More)
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Highly Cited
1998
Highly Cited
1998
Phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) is a key molecule involved in cell growth signaling. We demonstrated… (More)
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Highly Cited
1998
Highly Cited
1998
Protein kinase B (PKB) is activated in response to phosphoinositide 3-kinases and their lipid products phosphatidylinositol 3,4… (More)
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Highly Cited
1996
Highly Cited
1996
A 145-kDa tyrosine-phosphorylated protein that becomes associated with Shc in response to multiple cytokines has been purified… (More)
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Highly Cited
1996
Highly Cited
1996
Recent evidence has suggested that activation of phosphoinositide 3-kinase (PI 3-kinase) is required for the activation of Akt-1… (More)
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