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phenyl methimazole

Known as: phenylmethimazole 
 
National Institutes of Health

Related topics

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3 relations

Broader (2)

MethimazoleThiones
analogs & derivatives

Papers overview

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2017
2017
TLR signaling inhibitor, phenylmethimazole, in combination with tamoxifen inhibits human breast cancer cell viability and migration
Heightened co-expression and dysregulated signaling associated with Toll-like receptor 3 (TLR3) and Wnt5a is an integral… Expand
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2013
2013
Phenylmethimazole Suppresses dsRNA-Induced Cytotoxicity and Inflammatory Cytokines in Murine Pancreatic Beta Cells and Blocks Viral Acceleration of Type 1 Diabetes in NOD Mice
Accumulating evidence supports a role for viruses in the pathogenesis of type 1 diabetes mellitus (T1DM). Activation of dsRNA… Expand
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2012
2012
Phenylmethimazole Blocks dsRNA-Induced IRF3 Nuclear Translocation and Homodimerization
Previous studies revealed that phenylmethimazole (C10) inhibits IRF3 signaling, preventing dsRNA-induction of type 1 interferon… Expand
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Highly Cited
2010
Highly Cited
2010
Phenylmethimazole blocks palmitate-mediated induction of inflammatory cytokine pathways in 3T3L1 adipocytes and RAW 264.7 macrophages.
Visceral adipocytes and associated macrophages produce and release excessive amounts of biologically active inflammatory… Expand
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2010
2010
Phenyl methimazole suppresses dextran sulfate sodium-induced murine colitis.
Ulcerative colitis is an autoimmune-inflammatory disease characterized by abnormally increased expression of Toll-like receptor-4… Expand
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2010
2010
Regulation of major histocompatibility complex gene expression in thyroid epithelial cells by methimazole and phenylmethimazole.
Increased expression of major histocompatibility complex (MHC) class-I genes and aberrant expression of MHC class-II genes in… Expand
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Highly Cited
2009
Highly Cited
2009
Phenylmethimazole Decreases Toll-Like Receptor 3 and Noncanonical Wnt5a Expression in Pancreatic Cancer and Melanoma Together with Tumor Cell Growth and Migration
Purpose: To evaluate whether (a) Wnt5a expression in pancreatic cancer and malignant melanoma cells might be associated with… Expand
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Highly Cited
2007
Highly Cited
2007
High basal levels of functional toll-like receptor 3 (TLR3) and noncanonical Wnt5a are expressed in papillary thyroid cancer and are coordinately decreased by phenylmethimazole together with cell…
High basal levels of TLR3 and Wnt5a RNA are present in papillary thyroid carcinoma (PTC) cell lines consistent with their… Expand
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Highly Cited
2005
Highly Cited
2005
Thyrocytes express a functional toll-like receptor 3: overexpression can be induced by viral infection and reversed by phenylmethimazole and is associated with Hashimoto's autoimmune thyroiditis.
Toll-like receptors (TLRs) initiate an innate immune response. TLR3 on dendritic cells recognize double-stranded (ds) RNA and… Expand
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Highly Cited
2004
Highly Cited
2004
Phenyl Methimazole Inhibits TNF-α-Induced VCAM-1 Expression in an IFN Regulatory Factor-1-Dependent Manner and Reduces Monocytic Cell Adhesion to Endothelial Cells1
Proinflammatory cytokine (e.g., TNF-α)-induced expression of endothelial cell adhesion molecules (ECAMs) on the lumenal surface… Expand
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