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peptide deformylase activity

Known as: PDF activity, formyl-L-methionyl peptide amidohydrolase activity, polypeptide deformylase activity 
Catalysis of the reaction: formyl-L-methionyl peptide + H2O = formate + methionyl peptide. [EC:3.5.1.88, GOC:jl]
National Institutes of Health

Papers overview

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2018
2018
Peptide deformylases from Vibrio parahaemolyticus phage and bacteria display similar deformylase activity and inhibitor binding clefts.
Unexpected peptide deformylase (PDF) genes were recently retrieved in numerous marine phage genomes. While various hypotheses… Expand
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2013
2013
Caffeic acid phenethyl ester (CAPE), an active component of propolis, inhibits Helicobacter pylori peptide deformylase activity.
Helicobacter pylori (H. pylori) is a major causative factor for gastrointestinal illnesses, H. pylori peptide deformylase (HpPDF… Expand
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2010
2010
Characterization of peptide deformylase homologues from Staphylococcus epidermidis.
The emergence of multi-drug-resistant strains of Staphylococcus epidermidis emphasizes the need to develop new antibiotics. The… Expand
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2004
2004
Increased peptide deformylase activity for N-formylmethionine processing of proteins overexpressed in Escherichia coli: application to homogeneous rubredoxin production.
Deformylation of the initiator N-formylmethionine does not always proceed to completion for proteins overexpressed in Escherichia… Expand
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2003
2003
The role of peptide deformylase in protein biosynthesis: A proteomic study
Recently we investigated the influence of classical and emerging antibiotics on the proteome of Bacillus subtilis including in… Expand
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2002
2002
Composes de n-formyle hydroxylamine en tant qu'inhibiteurs de peptidyle deformylase (pdf)
La presente invention concerne le N-[1-oxo-2-alkyl-3-(N-hydroxyformamido)-propyl]-(carbonylamino-aryl ou heteroaryl)-azacyclo 4-7… Expand
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Highly Cited
1998
Highly Cited
1998
Control of peptide deformylase activity by metal cations.
Previous work indicated that peptide deformylase behaves as a metalloenzyme since the Escherichia coli enzyme was shown to… Expand
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Highly Cited
1993
Highly Cited
1993
Evidence that peptide deformylase and methionyl-tRNA(fMet) formyltransferase are encoded within the same operon in Escherichia coli.
Overexpression of the fms gene, the first translation unit of a dicistronic operon that also encodes methionyl-tRNA(fMet… Expand
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